[The therapeutic effect of probiotics on allergic rhinitis：a Meta analysis]

Objective:To systemically review the therapeutic effect of probitics on allergic rhinitis（AR).Method:Literatures about the effect of probitics on AR were searched in PubMed. The Cochrane Library, Web of Science and CNKI, WanFang Data and VIP inception to April 2016,and 2 reviewers independently screened literatures according to the inclusion and exclusion criteria, extracted data, and assessed the risk of bias of included studies. Then meta-analysis was performed using RevMan5.2 software. Result:A total of 16RCTs involving1374 patients were included in the meta-analysis, including 809 cases in the probitic group and 568 cases in the placebo group. The results of meta-analysis showed that the efficacy of probitic group was superior to the placebo group in total RQLQ,nasal RQLQ,eye RQLQ and the serum eosinophil count,the difference was statistically significant ［MD=-4.43,95%CI（-8.65~-0.20）;MD=-1.08，95%CI（-1.89~0.27）;MD=-0.95,95%CI（-1.46~-1.44）;MD=-28.40,95%CI（-43.53~-13.26）］.There was no significant difference in Serum IgE between the probitic group and the placebo group(P>0.05).There was no significant difference in the NTSS value between the lactobacillus group and the bifidobacterium group(P>0.05). Conclusion:Compared to the placebo, probitics can effectively reduce symptom scores of patients with AR;and different strains of probitics indicated no significant differences in improving nasal symptoms.