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Updated: Jun 19, 2026

Three-dimensional Optical-resolution Photoacoustic Microscopy
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Single beam acoustic trapping.

Jungwoo Lee, Shia-Yen Teh, Abraham Lee

    Applied Physics Letters
    |October 3, 2009
    PubMed
    Summary
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    A simple acoustic device can trap single lipid droplets using low-intensity sound waves, similar to optical tweezers. This method offers a new way to manipulate larger particles with forces up to hundreds of nanonewtons.

    Area of Science:

    • Acoustic manipulation
    • Biophysics
    • Particle trapping

    Background:

    • Optical tweezers are widely used for manipulating microscopic particles.
    • Existing methods may have limitations for larger particles or specific force requirements.

    Purpose of the Study:

    • To investigate the potential of a single beam acoustic device for trapping lipid droplets.
    • To compare acoustic trapping with optical tweezers for particle manipulation.

    Main Methods:

    • Utilizing a single beam acoustic device with low intensity.
    • Applying forces in the order of hundreds of nanonewtons.
    • Directing lipid droplets toward the beam focus within a specific range.

    Main Results:

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    Construction of a High Resolution Microscope with Conventional and Holographic Optical Trapping Capabilities
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    Published on: April 22, 2013

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    Last Updated: Jun 19, 2026

    Three-dimensional Optical-resolution Photoacoustic Microscopy
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    Construction of a High Resolution Microscope with Conventional and Holographic Optical Trapping Capabilities
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    Construction of a High Resolution Microscope with Conventional and Holographic Optical Trapping Capabilities

    Published on: April 22, 2013

  • Successfully trapped a single lipid droplet using the acoustic device.
  • Demonstrated trapping capabilities comparable to optical tweezers.
  • Achieved manipulation of particles with forces in the hundreds of nanonewtons.

    • Conclusions:

    • Single beam acoustic devices offer a viable and simple method for trapping lipid droplets.
    • This technique is suitable for particle manipulation involving larger particles or higher forces.
    • Acoustic trapping presents a promising alternative for specific applications in biophysics and particle manipulation.