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Updated: Jun 19, 2026

Murine Model of Leukemia Relapse to Induction Chemotherapy for Acute Lymphoblastic Leukemia
Published on: October 17, 2025
Can treating the SYK cell cure leukemia?
1Department of Pathology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA. james.downing@stjude.org
Abstract:
Targeted therapy has remained elusive for most acute myeloid leukemia patients. In this issue of Cancer Cell, Stegmaier and colleagues identify SYK as a key mediator of the differentiation block seen in this disease. Their data suggest that SYK inhibition may be an effective therapy for a significant proportion of AMLs.
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