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Brain dysfunction in multiple chemical sensitivity.
Ramon Orriols1, Roser Costa, Gemma Cuberas
1Servei de Pneumologia, Hospital Universitari Vall d' Hebron, Barcelona, Catalonia, Spain. rorriols@vhebron.net
Journal of the Neurological Sciences
|October 6, 2009
Summary
Multiple Chemical Sensitivity (MCS) patients exhibit brain dysfunction and neurocognitive decline after chemical exposure. This study suggests a neurogenic origin for MCS, impacting olfactory and cognitive brain regions.
Area of Science:
- Neuroscience
- Toxicology
- Psychiatry
Background:
- Multiple Chemical Sensitivity (MCS) is a chronic disorder with unknown causes.
- Investigating brain changes and cognitive function in MCS patients is crucial.
Purpose of the Study:
- To determine if MCS patients show brain SPECT and psychometric changes after chemical challenge.
- To explore the neurobiological underpinnings of MCS.
Main Methods:
- Brain SPECT imaging and psychometric scales were used in 8 MCS patients and healthy controls.
- Chemicals at non-toxic concentrations were administered to assess responses.
- Baseline and post-challenge data were compared between groups.
Main Results:
- MCS patients showed baseline hypoperfusion in specific cortical areas.
- Chemical challenge induced further hypoperfusion in olfactory and limbic regions in MCS patients.
- Controls exhibited hyperperfusion in certain brain areas post-challenge.
- MCS patients experienced worsened quality of life and neurocognitive function after exposure.
Conclusions:
- Chemical exposure triggers neurocognitive impairment and brain SPECT dysfunction in MCS patients.
- Dysfunction is particularly noted in odor-processing areas, suggesting a neurogenic origin.
- Findings support a neurobiological basis for Multiple Chemical Sensitivity.
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