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Updated: Jan 22, 2026
04:44
Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
Published on: June 16, 2020
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[Diffuse systemic sclerosis after occupational exposure to trichloroethylene and perchloroethylene]
P Pralong1, A Cavailhes, B Balme
1Service de dermatologie, centre hospitalier de Valence, 59, boulevard Pinel, 69500 Bron, France.
Annales De Dermatologie Et De Venereologie
|October 6, 2009
Summary
Diffuse systemic sclerosis (DSS) can be caused by occupational solvent exposure. Early prevention and diagnosis are crucial following exposure to trichloroethylene (TCE) and perchloroethylene (PCE).
Area of Science:
- Environmental Health
- Toxicology
- Immunology
Background:
- Diffuse systemic sclerosis (DSS) is an autoimmune condition.
- While often endogenous, DSS can arise from occupational exposures.
Observation:
- A case of DSS developed after prolonged intermittent occupational exposure to trichloroethylene (TCE) and perchloroethylene (PCE).
- The patient experienced rapid fatality due to cardiac arrest, linked to myocardial fibrosis.
Findings:
- Occupational exposure to TCE and PCE can induce diffuse systemic sclerosis.
- Myocardial fibrosis leading to cardiac arrest is a potential fatal outcome.
Implications:
- Increased awareness and systematic prevention strategies for DSS are needed in occupational settings with TCE/PCE exposure.
- Enhanced diagnostic protocols should be considered for individuals with potential TCE/PCE exposure and symptoms suggestive of DSS.
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