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DNA methylation protects hematopoietic stem cell multipotency from myeloerythroid restriction

Ann-Marie Bröske1, Lena Vockentanz, Shabnam Kharazi

  • 1Max Delbrück Center for Molecular Medicine, Berlin, Germany.

Nature Genetics
|October 6, 2009
PubMed
Summary

DNA methylation is crucial for hematopoietic stem cell (HSC) self-renewal and prevents premature differentiation. Methylation levels dynamically regulate stem cell fate in normal tissues and leukemia.

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