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Published on: July 24, 2021
The pharmacy of ceftazidime
B L Richardson1, J D Woodford, G D Andrews
1Glaxo Group Research Ltd, Greenford, Middlesex UB6 0HE, England.
The Journal of Antimicrobial Chemotherapy
|October 7, 2009
Summary
Ceftazidime for injection remains stable when dry and stored at 25°C. Reconstituted solutions and intravenous admixtures should be used within 6-24 hours to ensure potency.
Area of Science:
- Pharmaceutical Sciences
- Clinical Pharmacy
- Drug Stability
Background:
- Ceftazidime is a third-generation cephalosporin antibiotic commonly used for serious infections.
- Understanding the stability of ceftazidime for injection is crucial for safe and effective clinical use.
- Proper storage and handling protocols are essential to maintain drug potency after reconstitution.
Purpose of the Study:
- To determine the stability of ceftazidime for injection in its dry form.
- To assess the compatibility and stability of reconstituted ceftazidime with common diluents and intravenous fluids.
- To establish appropriate storage conditions and usage timelines for reconstituted ceftazidime.
Main Methods:
- Stability testing of ceftazidime for injection in the dry state at 25°C.
- Compatibility studies of reconstituted ceftazidime with water for injections and lignocaine hydrochloride injection (1.0% w/v).
- Evaluation of ceftazidime stability in various commonly used intravenous fluids.
Main Results:
- Ceftazidime for injection demonstrated essential stability in the dry state, allowing storage at 25°C.
- In solution, a slow loss of potency was observed.
- Reconstituted vials with water for injections or lignocaine hydrochloride injection should be used within 6 hours at room temperature.
- Dilute solutions in most intravenous fluids are stable for 24 hours at room temperature, except for sodium bicarbonate solutions (6 hours).
Conclusions:
- Ceftazidime for injection is stable when stored dry at controlled room temperature.
- Timely administration of reconstituted ceftazidime is necessary to prevent significant potency loss.
- Specific usage timelines should be followed based on the diluent and storage conditions.
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