Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Laminins are the Adhesive Proteins of Basal Lamina

Laminins are the Adhesive Proteins of Basal Lamina

Laminins are heterotrimeric proteins with high molecular mass found in the extracellular matrix. Each laminin molecule is composed of three chains, viz. alpha, beta, and gamma, coded by five, four, and three paralogous genes, respectively. Laminins are categories based on the compositions of the three chains.
In humans, the five forms of alpha chains are LAMA 1, LAMA 2, LAMA 3, LAMA 4, and LAMA 5. The four forms of beta chains are LAMB 1, LAMB 2, LAMB 3, and LAMB 4. The three forms of gamma...

Types of Intermediate Filaments

Types of Intermediate Filaments

The intermediate filaments are an essential component of the cytoskeleton. Presently six types of intermediate filament have been identified. Type I and II are acidic and basic keratin proteins. Type III is of mesodermal origin and comprises four proteins: vimentin, desmin, glial fibrillary acidic protein (GFAP), and peripherin. Vimentin is commonly found in mesenchymal cells, desmin in muscle cells, GFAP in astrocytes, while peripherin is found in peripheral nervous system neurons (PNS). Type...

Disassembly of Intermediate Filaments

Disassembly of Intermediate Filaments

Intermediate filaments (IFs) do not undergo spontaneous disassembly. Enzymes, kinases, and phosphatases add and remove phosphates from specific sites to regulate their disassembly. The IF concentration in the cytoplasm also regulates the disassembly. If the concentration crosses a threshold, it activates the protein kinases in the vicinity, allowing the phosphorylation of IFs.
Keratin proteins, found at the cell periphery near cell junctions, undergo a cycle of assembly and disassembly. In Type...

Mechanism of Lamellipodia Formation

Mechanism of Lamellipodia Formation

Cells migrating in response to external stimuli form lamellipodia, which are thin membrane protrusions supported by a mesh of linked, branched, or unbranched actin filaments. These actin filaments interact with myosin motor proteins, creating the dynamic actomyosin complex within the cytoskeleton. Contractility, or the ability to generate contractile stress, is inherent to the actomyosin complex. It helps cells detect the stiffness of the surrounding ECM and exert contractile force for...

Type IV Collagen of Basal Lamina

Type IV Collagen of Basal Lamina

Type IV collagen is a 400 nm long, network-forming collagen that acts as a barrier between the epithelial and endothelial cells. Type IV collagen forms the backbone of the basement membrane by scaffolding with laminin, entactin, proteoglycans, and fibronectin. Apart from rendering structural support to the basement membrane, it also helps entail signaling potentials necessary for both pathological and physiological functions.
A type IV collagen molecule has six alpha chains which can exist in...

Cytoskeletal Linker Proteins - Plakins

Cytoskeletal Linker Proteins - Plakins

Plakins are large proteins with binding domains for microtubules, microfilaments, intermediate filaments, and membrane-associated protein complexes at cell junctions. Plakin functions are evolutionarily conserved and are primarily involved in organizing the different components of the cytoskeleton by crosslinking them to each other and connecting them to the cell-matrix and cell adhesion complexes. They are also known to interact with signal transducers, serve as scaffolds for signaling...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

The Novel HLA-DRB1*15:02:21 Allele, Identified by Sanger Dideoxy Nucleotide Sequencing in a Chinese Individual.

HLA·2026

Same author

CDK8/CDK19 inhibition restores T-cell homeostasis in primary immune thrombocytopenia.

Blood·2026

Same author

The Genetic Link Between Primary Immune Thrombocytopenia and Depression/Anxiety Disorders: A Two-Sample Mendelian Randomization Study.

Journal of clinical laboratory analysis·2026

Same author

The biological functions of protein lactylation.

Sheng li xue bao : [Acta physiologica Sinica]·2025

Same author

UFMylation: A supervisor of the HIF1α pathway and a potential therapeutic target for anti-PD-1 combination therapy in hypoxic tumors.

Proceedings of the National Academy of Sciences of the United States of America·2025

Same author

Effects of orelabrutinib, a BTK inhibitor, on antibody-mediated platelet destruction in primary immune thrombocytopenia.

British journal of haematology·2025

Same journal

[Mechanical regulation mechanism on vascular remodeling induced by hypertension].

Sheng li ke xue jin zhan [Progress in physiology]·2018

Same journal

[Progress on research methods of transcription factors].

Sheng li ke xue jin zhan [Progress in physiology]·2018

Same journal

[Regulatory effect of miR-21 on peripheral nerve injury and regulation function].

Sheng li ke xue jin zhan [Progress in physiology]·2018

Same journal

[The protective effects and mechanisms of PPARγ in ischemia-reperfusion injury of tissues].

Sheng li ke xue jin zhan [Progress in physiology]·2018

Same journal

[Nitric Oxide Signaling Pathway and Vascular Activity].

Sheng li ke xue jin zhan [Progress in physiology]·2018

Same journal

[The Regulation Effects of Carbon Monoxide in Cardiovascular Systems].

Sheng li ke xue jin zhan [Progress in physiology]·2018

See all related articles

Search research articles

Related Experiment Video

Updated: Jun 19, 2026

Detection of Nuclear Blebbing and DNA Leakage in Mammalian Cells by Immunofluorescence

Detection of Nuclear Blebbing and DNA Leakage in Mammalian Cells by Immunofluorescence

Published on: January 17, 2025

[Research progress in A-type lamins].

Chun-Hai Gao¹, Xin-Guang Liu, Zhong-Jun Zhou

¹Institute of Biochemistry Molecular Biology, Guangdong Medical College, Zhanjiang 524023, China.

Sheng Li Ke Xue Jin Zhan [Progress in Physiology]

|October 7, 2009

Summary

This summary is machine-generated.

A-type lamins, encoded by LMNA, support the nuclear lamina and organize chromatin. Mutations in LMNA cause laminopathies, a group of human diseases.

More Related Videos

Generating a Fractal Microstructure of Laminin-111 to Signal to Cells

Generating a Fractal Microstructure of Laminin-111 to Signal to Cells

Published on: September 28, 2020

Validation of a Mouse Model to Disrupt LINC Complexes in a Cell-specific Manner

Validation of a Mouse Model to Disrupt LINC Complexes in a Cell-specific Manner

Published on: December 10, 2015

Related Experiment Videos

Last Updated: Jun 19, 2026

Detection of Nuclear Blebbing and DNA Leakage in Mammalian Cells by Immunofluorescence

Detection of Nuclear Blebbing and DNA Leakage in Mammalian Cells by Immunofluorescence

Published on: January 17, 2025

Generating a Fractal Microstructure of Laminin-111 to Signal to Cells

Generating a Fractal Microstructure of Laminin-111 to Signal to Cells

Published on: September 28, 2020

Validation of a Mouse Model to Disrupt LINC Complexes in a Cell-specific Manner

Validation of a Mouse Model to Disrupt LINC Complexes in a Cell-specific Manner

Published on: December 10, 2015

Area of Science:

Cell Biology
Molecular Biology
Genetics

Context:

A-type lamins are key structural proteins of the nuclear lamina, essential for nuclear envelope integrity and mechanical support.
They interact with chromatin, influencing crucial cellular processes like gene transcription and DNA replication.

Purpose:

This review synthesizes current knowledge on A-type lamins, focusing on their structure, modifications, assembly, and interactions.
It aims to elucidate the multifaceted roles of A-type lamins in cellular functions and their implications in human diseases.

Summary:

A-type lamins, encoded by the LMNA gene, form the nuclear lamina, providing mechanical support and regulating chromatin organization, transcription, DNA replication, and apoptosis.
Dysfunctional A-type lamins due to LMNA mutations lead to a spectrum of inherited disorders known as laminopathies.

Impact:

Understanding A-type lamin biology is crucial for deciphering the pathogenesis of laminopathies.
This review provides a comprehensive resource for researchers investigating nuclear structure, gene regulation, and related human diseases.