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Updated: Jun 19, 2026

RNA-seq Analysis of Transcriptomes in Thrombin-treated and Control Human Pulmonary Microvascular Endothelial Cells
Published on: February 13, 2013
Platelet transcriptome and cardiovascular disease
Lisa Senzel1, Dmitri V Gnatenko, Wadie F Bahou
1State University of New York, Department of Pathology, Stony Brook, NY, USA. lsenzel@notes.cc.sunysb.edu
Abstract:
Platelet hyper-reactivity is likely to play a role in cardiovascular disease, but there are no standardized tests to evaluate platelet responsiveness. A 'platelet chip' (a synthetic oligonucleotide microarray representing all platelet-restricted genes) is under development as a tool for high-throughput characterization of platelet-based bleeding and clotting disorders. In future, platelet gene profiling may be used to improve thrombohemorrhagic risk assessment and to guide antiplatelet therapy for patients at risk of cardiovascular disease.
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