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Updated: Jun 19, 2026

Monitoring Functionality and Morphology of Vasculature Recruited by Factors Secreted by Fast-growing Tumor-generating Cells
Published on: November 23, 2014
Chemokines in tumor-associated angiogenesis
Peter Arne Gerber1, Andreas Hippe, Bettina Alexandra Buhren
1Department of Dermatology, University Hospital Düsseldorf, D-40225 Düsseldorf, Germany.
Tumor growth relies on new blood vessel formation (angiogenesis). Chemokines, involved in cell migration, also promote tumor angiogenesis, supplying nutrients and enabling metastasis. Targeting chemokines offers a promising cancer therapy strategy.
Area of Science:
- Oncology
- Immunology
- Cell Biology
Background:
- Tumor growth beyond 2 micrometers requires oxygen and nutrients, necessitating tumor-associated angiogenesis.
- While vascular endothelial growth factor is a known angiogenic factor, chemokines also play a role in blood vessel formation.
- Chemokines regulate leukocyte, stem cell, and cancer cell migration and trafficking, influencing the tumor microenvironment.
Purpose of the Study:
- To discuss the role of chemokines in tumor-associated angiogenesis.
- To explore the pathogenetic concepts of chemokine-driven angiogenesis in tumors.
- To highlight therapeutic strategies targeting chemokines for cancer treatment.
Main Methods:
- Literature review of pathogenetic concepts.
- Analysis of the role of chemokines and their receptors in angiogenesis.
- Discussion of current and emerging therapeutic strategies.
Main Results:
- Chemokines are implicated in promoting tumor-associated angiogenesis, crucial for nutrient and oxygen supply.
- Chemokine-mediated angiogenesis facilitates tumor growth and is a prerequisite for metastasis.
- Complex interactions between tumors and associated vessels are vital for chemokine-promoted angiogenesis.
Conclusions:
- Chemokines are key regulators of tumor-associated angiogenesis.
- Targeting chemokines and their receptors presents a promising therapeutic avenue for anticancer drugs.
- Understanding chemokine pathways is essential for developing novel cancer therapies.
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