Behavioral genetic analysis of regional mouse brain biogenic amines, acidic metabolites and motor activity

¹Department of Pharmacology, University of North Dakota School of Medicine, Grand Forks 58203.

Comparative Biochemistry and Physiology. C, Comparative Pharmacology and Toxicology

|January 1, 1990

Abstract:

1. Comparative analyses of regional brain biogenic amines and spontaneous locomotor activity of three mouse strains suggest a genotype dependent relationship. 2. A positive correlation between striatal dopamine and locomotor activity was determined in the inbred albino BALB/c mouse strain. 3. An inverse relationship between some brain regions serotonin and motility was found in the inbred black C57BL/6 mouse strain. 4. No correlation could be established between brain monoamines and motor activity in the hybrid CDF-1 mouse strain. 5. The results suggest that inbred BALB/c and C57BL/6 mouse strains may be useful animal models for studying dopaminergic and serotonergic acting agents, respectively.

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Abstract:

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