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Updated: Jun 19, 2026

Screening Assays to Characterize Novel Endothelial Regulators Involved in the Inflammatory Response

Screening Assays to Characterize Novel Endothelial Regulators Involved in the Inflammatory Response

Published on: September 15, 2017

Group differences in proneness to inflammation.

Renee Pennington¹, Chandler Gatenbee, Brett Kennedy

¹Department of Anthropology, University of Utah, 270 S 1400 E, Salt Lake City, UT 84112, USA.

Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases

|October 7, 2009

Summary

This summary is machine-generated.

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Human immune systems evolved differently based on ancestral pathogen exposure. Recent African ancestry correlates with a "tuned up" immune response, potentially increasing inflammatory disease risk in modern populations.

Area of Science:

Human evolutionary biology
Immunology
Population genetics

Background:

Humans originated from an African diaspora ~50,000 years ago, with some archaic admixture.
Historical infectious disease burden varied geographically, being higher in tropical Africa and lower in the New World due to the Beringian filter.

Purpose of the Study:

To investigate how evolved immune system responses to differing pathogen burdens across geographic ancestries may influence inflammatory disease rates.
To hypothesize differential immune "tuning" based on ancestral pathogen exposure.

Main Methods:

Comparative analysis of historical infectious disease prevalence across continents.
Inference of immune system adaptation based on geographic ancestry and pathogen exposure models.

Related Experiment Videos

Last Updated: Jun 19, 2026

Screening Assays to Characterize Novel Endothelial Regulators Involved in the Inflammatory Response

Screening Assays to Characterize Novel Endothelial Regulators Involved in the Inflammatory Response

Published on: September 15, 2017

Main Results:

Immune systems are expected to be "tuned up" in populations with recent tropical African ancestry.
Intermediate immune tuning is anticipated in European and Asian ancestries.
A "tuned down" immune response is hypothesized for Native American ancestries.

Conclusions:

Evolved immune responses to diverse pathogen loads may explain differential rates of inflammatory diseases in modern populations.
Ancestral pathogen pressure is a significant factor shaping contemporary human immune function and disease susceptibility.