[Hypertension in solid organ transplants]

Area of Science:

• Nephrology
• Cardiology
• Transplantation Medicine

Context:

• Hypertension is highly prevalent in organ transplant recipients.
• Calcineurin inhibitors improve allograft survival but increase cardiovascular risks.
• Cardiovascular complications are a major cause of morbidity and mortality in this population.

Purpose:

• To review the epidemiology and physiopathology of hypertension in transplant recipients.
• To discuss the clinical management of hypertension in transplant patients.
• To highlight the lack of specific evidence for blood pressure targets and control strategies.

Summary:

• Organ transplant recipients frequently develop hypertension, a significant risk factor for cardiovascular disease.
• While immunosuppressants like calcineurin inhibitors enhance graft survival, they contribute to hypertension and other cardiovascular complications.
• Effective management strategies and specific blood pressure targets for transplant recipients remain under-researched.

Impact:

• Informs clinical practice regarding hypertension management in transplant patients.
• Highlights the need for further research into optimal blood pressure control in this vulnerable population.
• Aims to improve long-term outcomes and reduce cardiovascular morbidity and mortality post-transplantation.