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The structure of the homeodomain and its functional implications
W J Gehring1, M Müller, M Affolter
1University of Basel, Switzerland.
Trends in Genetics : TIG
|October 1, 1990
Abstract:
The three-dimensional structure of the homeodomain, as determined by nuclear magnetic resonance spectroscopy, reveals the presence of a helix-turn-helix motif, similar to the one found in prokaryotic gene regulatory proteins. Isolated homeodomains bind with high affinity to specific DNA sequences. Thus, the structure-function relationship is highly conserved in evolution.