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Updated: Jun 19, 2026

Studying the Hypothalamic Insulin Signal to Peripheral Glucose Intolerance with a Continuous Drug Infusion System into the Mouse Brain
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Published on: January 4, 2018

Does hypothalamic inflammation cause obesity?

Brent E Wisse1, Michael W Schwartz

  • 1Department of Medicine, Diabetes and Obesity Center of Excellence, University of Washington, Seattle, WA 98195, USA.

Cell Metabolism
|October 8, 2009
PubMed
Summary

Obesity causes inflammation, leading to insulin and leptin resistance. This study shows this resistance occurs in the hypothalamus, explaining how high-fat diets increase body weight.

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