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Can we personalize treatment for kidney diseases?
Brad H Rovin1, Alison M McKinley, Daniel J Birmingham
1Division of Nephrology, Department of Internal Medicine, Ohio State University College of Medicine, Columbus 43210, OH 43210, USA. rovin.1@osu.edu
Clinical Journal of the American Society of Nephrology : CJASN
|October 8, 2009
Summary
Personalized medicine offers tailored treatments for kidney diseases by considering individual patient factors. Further research investment is crucial for its routine clinical application in nephrology.
Area of Science:
- Nephrology
- Pharmacogenomics
- Biomarker research
Background:
- Individualized therapy for optimal outcomes is a growing concept.
- Kidney diseases offer significant potential for personalized medicine approaches.
- The heterogeneity of kidney disorders supports the need for tailored treatments.
Purpose of the Study:
- To review the heterogeneity of kidney disorders as a rationale for personalized medicine.
- To summarize current data on pharmacogenetics/genomics and pharmacodynamics in kidney disease therapy.
- To discuss biomarker studies representing the future of personalized nephrology.
Main Methods:
- Review of existing literature on personalized medicine in kidney diseases.
- Analysis of pharmacogenetic/genomic and pharmacodynamic data.
- Discussion of emerging biomarker studies.
Main Results:
- Kidney disorders exhibit heterogeneity, supporting personalized treatment strategies.
- Pharmacogenetics, genomics, and pharmacodynamics are key to adjusting therapies.
- Biomarker research indicates a promising future for personalized nephrology.
Conclusions:
- Personalized therapy for kidney diseases is achievable.
- Significant research investment is necessary for routine clinical implementation.
- Personalized medicine holds the potential to revolutionize nephrology care.
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