[Immunomorphological characteristics of experimental granulomatous inflammation caused by Mycobacterium avium]

The results of the topical arrangement of T and B lymphocytes in the lung tissue granulomatous masses of the mice susceptible (C57BL/6Ycit) and resistant (I/StSnEgYCit) to aerosol inoculation with M. avium 724R in a dose of 2 x 10(3) CFU/mice are presented by means of labeled monoclonal antibodies. At week 8 of the inoculation, CD4+ lymphocytes were located both among the granuloma cells in the diffuse fashion and as small clusters and in the interalveolar and interlobular septa in the B6 mice and these were mainly in the granuloma in the I/St mice. At week 16, CD8+ lymphocytes were found in the peripheral granuloma portions in the B6 mice and these were diffusely throughout the area of granulomatous masses in the I/St mice. In the B6 mice, CD19+ lymphocytes formed cell aggregates from week 8 of the inoculation; and in the I/st mice, these were diffusely located among the granuloma cells and abundantly in the interalveolar and interlohular septa.