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Multidrug-resistant Gram-negative bacteria in postoperative infections
Ajay Vir Singh1, Bibhabati Mishra, Archana Thakur
1Department of Microbiology, GB Pant Hospital, New Delhi 110002.
Journal of the Indian Medical Association
|October 9, 2009
Summary
Multidrug-resistant Gram-negative bacteria are a significant concern in hospital-associated infections. This study found a 9.45% prevalence, with Escherichia coli and Klebsiella being most common, and identified key effective antibiotics.
Area of Science:
- Medical Microbiology
- Infectious Diseases
- Hospital Epidemiology
Background:
- Gram-negative bacteria cause significant hospital-associated infections.
- Antimicrobial resistance in these pathogens is a major clinical concern.
Purpose of the Study:
- To identify Gram-negative bacteria from clinical samples of postoperative patients.
- To determine their antibiotic susceptibility patterns.
- To assess the prevalence of multidrug-resistant Gram-negative bacteria.
Main Methods:
- Isolation and identification of Gram-negative bacteria from clinical samples.
- Antibiotic susceptibility testing against 14 different antimicrobial agents.
- Prevalence calculation of multidrug-resistant isolates.
Main Results:
- The overall prevalence of multidrug-resistant Gram-negative bacteria was 9.45%.
- Highest prevalence was observed in the gastrointestinal (GI) surgery department.
- Escherichia coli and Klebsiella were the most frequently isolated species.
- Amikacin, meropenem, piperacillin + tazobactam, and cefoperazone + sulbactam showed the highest sensitivity rates against resistant isolates.
Conclusions:
- Multidrug-resistant Gram-negative bacteria pose a substantial threat in postoperative infections, particularly in GI surgery.
- Effective antibiotic options for these resistant strains include amikacin, meropenem, piperacillin + tazobactam, and cefoperazone + sulbactam.
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