Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Biological Effects of Radiation

Biological Effects of Radiation

All radioactive nuclides emit high-energy particles or electromagnetic waves. When this radiation encounters living cells, it can cause heating, break chemical bonds, or ionize molecules. The most serious biological damage results when these radioactive emissions fragment or ionize molecules. For example, α and β particles emitted from nuclear decay reactions possess much higher energies than ordinary chemical bond energies. When these particles strike and penetrate matter, they produce ions...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Development of a Core Outcome Domain Set for Facial Aging.

JAMA dermatology·2026

Same author

Evaluation of tumor localization accuracy on fast ring-gantry cone-beam computed tomography using patient-specific breathing curves and a dynamic anthropomorphic thorax phantom.

Physics and imaging in radiation oncology·2026

Same author

A standardized workflow for the development and manufacturing of tissue-equivalent anthropomorphic phantoms for radiotherapy using 3D-printing.

Physics in medicine and biology·2026

Same author

Development of a core outcome set for clinical trials in melasma.

Journal of the American Academy of Dermatology·2026

Same author

Assessing dosimetric uncertainties in Papillon+ contact x-ray brachytherapy for rectal cancer: impact of beam quality and tumour geometry.

Physics in medicine and biology·2026

Same author

Evaluation of proton range differences in photon-counting and dual-energy computed tomography across imaging doses and anthropomorphic phantom sizes.

Physics in medicine and biology·2026

Same journal

Correction to "On the shape of the radiation survival curve in tumor spheroids: The role of oxygen heterogeneity".

Medical physics·2026

Same journal

Multi-view constrained semi-supervised vertebra detection for 3D ultrasound spine volume.

Medical physics·2026

Same journal

Accuracy of quantitative <sup>177</sup>Lu SPECT/CT imaging: A systematic review.

Medical physics·2026

Same journal

Physics-constrained dual-domain network for CBCT reconstruction from orthogonal X-rays in gynecologic radiotherapy.

Medical physics·2026

Same journal

Decomposition-based harmonization for quantitative PET imaging across scanners and radiotracers.

Medical physics·2026

Same journal

Development and evaluation of an in vivo dose-based monitoring system for electron FLASH radiation therapy.

Medical physics·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Jun 19, 2026

Irradiator Commissioning and Dosimetry for Assessment of LQ α and β Parameters, Radiation Dosing Schema, and in vivo Dose Deposition

Irradiator Commissioning and Dosimetry for Assessment of LQ α and β Parameters, Radiation Dosing Schema, and in vivo Dose Deposition

Published on: March 11, 2021

A CT-based analytical dose calculation method for HDR 192Ir brachytherapy.

Emily Poon¹, Frank Verhaegen

¹Medical Physics Unit, McGill University, 1650 Cedar Avenue, Montreal, Quebec H3G 1A4, Canada.

Medical Physics

|October 9, 2009

Summary

This summary is machine-generated.

A new analytical method improves high-dose-rate 192Ir brachytherapy dose calculations by accounting for tissue variations. This approach is accurate and efficient for treatment planning, outperforming traditional methods in complex cases.

More Related Videos

Positron Emission Tomography-based Dose Painting Radiation Therapy in a Glioblastoma Rat Model using the Small Animal Radiation Research Platform

Positron Emission Tomography-based Dose Painting Radiation Therapy in a Glioblastoma Rat Model using the Small Animal Radiation Research Platform

Published on: March 24, 2022

Expedited Radiation Biodosimetry by Automated Dicentric Chromosome Identification (ADCI) and Dose Estimation

Expedited Radiation Biodosimetry by Automated Dicentric Chromosome Identification (ADCI) and Dose Estimation

Published on: September 4, 2017

Related Experiment Videos

Last Updated: Jun 19, 2026

Irradiator Commissioning and Dosimetry for Assessment of LQ α and β Parameters, Radiation Dosing Schema, and in vivo Dose Deposition

Irradiator Commissioning and Dosimetry for Assessment of LQ α and β Parameters, Radiation Dosing Schema, and in vivo Dose Deposition

Published on: March 11, 2021

Positron Emission Tomography-based Dose Painting Radiation Therapy in a Glioblastoma Rat Model using the Small Animal Radiation Research Platform

Positron Emission Tomography-based Dose Painting Radiation Therapy in a Glioblastoma Rat Model using the Small Animal Radiation Research Platform

Published on: March 24, 2022

Expedited Radiation Biodosimetry by Automated Dicentric Chromosome Identification (ADCI) and Dose Estimation

Expedited Radiation Biodosimetry by Automated Dicentric Chromosome Identification (ADCI) and Dose Estimation

Published on: September 4, 2017

Area of Science:

Medical Physics
Radiation Oncology
Radiotherapy Physics

Background:

High-dose-rate (HDR) 192Iridium (Ir) brachytherapy is a crucial cancer treatment.
Accurate dose calculation is essential for effective treatment planning and patient safety.
Current methods like Task Group 43 (TG-43) may have limitations in complex anatomical scenarios.

Purpose of the Study:

To develop and validate an analytical dose calculation method for HDR 192Ir brachytherapy.
To assess the adequacy of the TG-43 formalism in the presence of tissue inhomogeneities and near-skin effects.
To improve the accuracy and efficiency of dose calculations in brachytherapy treatment planning.

Main Methods:

An analytical method using CT-derived data for material composition and density was employed.
Dose distributions were initially calculated in water, then corrected for inhomogeneities using ray tracing.
Monte Carlo (MC) simulations and gamma index analysis (3%/2mm) were used for validation against PTRAN_CT MC calculations.

Main Results:

The analytical method achieved 100% gamma index passing rates in phantoms with inserts.
For breast brachytherapy, TG-43 overestimated target dose and skin dose, while the analytical method agreed with MC within 0.4%.
TG-43 showed significantly lower passing rates (48%) compared to the analytical method (100%) for breast plans, though both performed well (>99%) in head-and-neck and esophagus cases.

Conclusions:

A validated, correction-based analytical dose calculation method is suitable for HDR 192Ir brachytherapy.
The method's high efficiency makes it practical for clinical treatment planning.
TG-43 is adequate for target dose estimation when tissue inhomogeneities are minor and shielding/contrast agents are absent.