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Updated: Jun 19, 2026

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies
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Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies

Published on: February 6, 2019

The M. D. Anderson proton therapy system.

Alfred Smith1, Michael Gillin, Martin Bues

  • 1Department of Radiation Oncology, The University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Boulevard, Houston Texas 77030, USA. alsmith@mdanderson.org

Medical Physics
|October 9, 2009
PubMed
Summary

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The University of Texas M. D. Anderson Cancer Center

Area of Science:

  • Medical Physics
  • Radiation Oncology
  • Particle Therapy

Background:

  • Proton therapy offers precise radiation delivery for cancer treatment.
  • Technological advancements are crucial for optimizing proton therapy systems.
  • The University of Texas M. D. Anderson Cancer Center (PTC-H) implemented a new proton therapy system.

Purpose of the Study:

  • To detail the University of Texas M. D. Anderson proton therapy system (PTC-H).
  • To describe system components: accelerator, beam transport, and treatment delivery.
  • To evaluate functionality, clinical parameters, and acceptance test results for passive scattering and pencil beam scanning.

Main Methods:

  • System description includes a synchrotron, four treatment rooms with gantries and fixed beamlines.

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Last Updated: Jun 19, 2026

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  • Two treatment modes: passive scattering (PS) and pencil beam scanning (PBS) for intensity-modulated proton therapy (IMPT) and single field uniform dose (SFUD).
  • Integration with Eclipse (Varian) for treatment planning and MOSAIQ (IMPAC) for data management; DICOM-RT ION interfaces used.

    • Main Results:

    • The proton therapy system successfully passed all acceptance tests for both PS and PBS modes.
    • Clinical operation commenced in May 2006 (PS) and May 2008 (PBS), achieving ~98% up-time.
    • PTC-H was the first commercial system for IMPT and first in the US for SFUD treatments.

    Conclusions:

    • The PTC-H system is robust, accurate, reproducible, and reliable.
    • Pencil beam scanning (PBS) system is particularly satisfactory, offering faster prostate treatment delivery.
    • Potential system upgrades were identified to further enhance performance.