Complex regional pain syndrome: an actual survey

Complex regional pain syndrome - in the past called sympathetic reflex dystrophy - is, in its pathophysiology, still not fully understood. However, research in the last few years has led to a better understanding of the illness and the beginning of a pathophysiologically- orientated therapy. The core hypothesis is based on neuropeptide release, neurogenic inflammation and its sympathetic dependence. Therapy should be based on current pathophysiological concepts regarding CRPS and neuropathic pain and could thereby lead to a good outcome of the illness.