Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Menses Phase01:18

Menses Phase

The uterine cycle begins with the menstrual phase, which is considered day one of the cycle and typically lasts about five days. This phase is characterized by the degeneration and shedding of the stratum functionalis, the functional layer of the endometrium.
When fertilization does not occur, the corpus luteum deteriorates, causing a significant drop in the levels of estrogen and progesterone in the body. This hormonal decrease triggers the release of prostaglandins, which cause the uterine...
The Menstrual Cycle01:19

The Menstrual Cycle

The menstrual cycle is a recurrent sequence of changes in the uterine endometrium, specifically its functional layer, the stratum functionalis. This cycle prepares the uterus for potential pregnancy. This cycle typically spans 21–35 days, averaging 28 days, and aligns with the ovarian cycle, regulated by fluctuating levels of ovarian hormones, primarily estrogen and progesterone.
The menstrual phase occurs from days 1 to 5 and involves the shedding of the stratum functionalis, as a uterine...
Hormonal Regulation of the Menstrual Cycle01:22

Hormonal Regulation of the Menstrual Cycle

The ovarian cycle regulates endometrial changes throughout a single menstrual cycle via the coordinated action of gonadotrophin-releasing hormone (GnRH) and gonadotrophins.
At puberty, GnRH begins a pulsatile release pattern, which triggers the anterior pituitary gland to secrete follicle-stimulating hormone (FSH) and luteinizing hormone (LH). The frequency and amplitude of GnRH pulses vary across the menstrual cycle, with faster pulses favoring LH release and slower pulses favoring FSH release.
Disorders of the Female Reproductive System01:24

Disorders of the Female Reproductive System

The female reproductive system can be affected by several disorders, including Premenstrual Syndrome (PMS), Premenstrual Dysphoric Disorder (PMDD), endometriosis, and various forms of cancer. PMS and PMDD are cyclical conditions that cause physical and emotional distress, with symptoms that include edema, mood swings, and food cravings. PMDD is a more severe form of PMS characterized by increased symptom severity that peaks during the luteal phase and tends to improve or resolve shortly after...
Menopause01:28

Menopause

Menopause, a natural biological process marking the end of a woman's fertility, typically occurs between the fifth and sixth decade of life. This phase is characterized by the exhaustion of the ovarian follicle pool, leading to less responsive ovaries despite the high levels of Follicle Stimulating Hormone (FSH) and Luteinizing Hormone (LH). The consequential decrease in estrogen production results in symptoms like hot flashes, heavy sweating, headaches, hair loss, muscle pains, vaginal...
Venous Thrombosis IV: Nursing Management01:30

Venous Thrombosis IV: Nursing Management

Nursing management begins with a thorough assessment of the patient's health history. Key factors include trauma to veins, peripherally inserted central catheters, varicose veins, recent pregnancy or childbirth, surgery, bacteremia, prolonged bed rest, atrial fibrillation, COPD, heart failure, cancer, coagulation disorders, myocardial infarction, spinal cord injury, stroke, prolonged travel, recent bone fractures, and dehydration. Review medication intake, particularly oral contraceptives,...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Update of the Australian Guideline for the Management of Cancer Pain in Adults.

Asia-Pacific journal of clinical oncology·2025
Same author

Assessing the digital health maturity of general practice in Australia: results from a cross-sectional national survey.

Australian journal of primary health·2025
Same author

Unmet Need for Breast Cancer Screening Among South Asian Women in Victoria.

Asia-Pacific journal of clinical oncology·2025
Same author

Molecular profiling of BRCA1/BRCA2 gene variants in Pakistani breast cancer patients.

JPMA. The Journal of the Pakistan Medical Association·2025
Same author

Ginsenoside Rg3 in Cancer Research: Current Trends and Future Prospects - A Review.

Current medicinal chemistry·2025
Same author

Chronic kidney disease and aging: dissecting the p53/p21 pathway as a therapeutic target.

Biogerontology·2024

Related Experiment Video

Updated: Jun 19, 2026

Herbs-Partitioned Moxibustion on the Navel in a Rat Model of Primary Dysmenorrhea with Cold Coagulation and Blood Stasis
05:36

Herbs-Partitioned Moxibustion on the Navel in a Rat Model of Primary Dysmenorrhea with Cold Coagulation and Blood Stasis

Published on: October 4, 2024

Body weight and bleeding pattern changes in women using DMPA-SC.

Rizwana Chaudhri1, Farwa Rizvi, Muhammad Afzal

  • 1Department of Gynaecology and Obstetrics, Holy Family Hospital, Rawalpindi.

Journal of the College of Physicians and Surgeons--Pakistan : JCPSP
|October 9, 2009
PubMed
Summary

Depot medroxyprogesterone acetate-subcutaneous (DMPA-SC) offers 100% contraceptive efficacy over one year with minimal weight gain. The injectable contraceptive also shows a trend towards amenorrhea, making it a suitable reversible option for women.

More Related Videos

Auricular Point Acupressure Therapy: A Safe and Effective Treatment for Postsurgical Abortion Recovery
07:28

Auricular Point Acupressure Therapy: A Safe and Effective Treatment for Postsurgical Abortion Recovery

Published on: February 3, 2026

Related Experiment Videos

Last Updated: Jun 19, 2026

Herbs-Partitioned Moxibustion on the Navel in a Rat Model of Primary Dysmenorrhea with Cold Coagulation and Blood Stasis
05:36

Herbs-Partitioned Moxibustion on the Navel in a Rat Model of Primary Dysmenorrhea with Cold Coagulation and Blood Stasis

Published on: October 4, 2024

Auricular Point Acupressure Therapy: A Safe and Effective Treatment for Postsurgical Abortion Recovery
07:28

Auricular Point Acupressure Therapy: A Safe and Effective Treatment for Postsurgical Abortion Recovery

Published on: February 3, 2026

Area of Science:

  • Reproductive Health
  • Endocrinology
  • Pharmacology

Background:

  • Depot medroxyprogesterone acetate-subcutaneous (DMPA-SC) is a progestin-only contraceptive injection administered every three months.
  • Understanding its long-term efficacy, impact on bleeding patterns, and weight changes is crucial for patient counseling and clinical practice.

Purpose of the Study:

  • To evaluate the one-year contraceptive efficacy of DMPA-SC.
  • To assess changes in menstrual bleeding patterns and body weight associated with DMPA-SC use.

Main Methods:

  • A descriptive case-series study was conducted over one year.
  • Twenty-five women received DMPA-SC injections every three months.
  • Body weight and bleeding patterns were monitored at three-month intervals.

Main Results:

  • DMPA-SC demonstrated 100% efficacy in preventing pregnancy among the 25 participants.
  • A mean weight gain of 1.036 kg was observed over the one-year study period.
  • A trend towards amenorrhea was noted, with 56% of patients experiencing reduced bleeding.

Conclusions:

  • DMPA-SC is a highly effective reversible contraceptive method.
  • It is associated with minimal weight gain and a favorable bleeding profile, often leading to amenorrhea.