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Related Concept Videos

Renal Failure: Dose Adjustments01:11

Renal Failure: Dose Adjustments

In patients with renal impairment, drugs undergo significant changes in their pharmacokinetics, which require dosage adjustments to ensure safe and effective therapy.
Reduced renal clearance and elimination rate are common outcomes of renal impairment. These alterations lead to a prolonged elimination half-life and an altered apparent volume of distribution for drugs. As a result, dosage adjustments are typically necessary to maintain optimal drug levels in the body.
However, dosage adjustments...
Chronic Kidney Disease II: Clinical Manifestations01:24

Chronic Kidney Disease II: Clinical Manifestations

Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...
Chronic Kidney Disease IV: Nursing Management01:18

Chronic Kidney Disease IV: Nursing Management

Nursing management is essential for preventing complications, maintaining stability, and improving patients' quality of life in chronic kidney disease (CKD). By using a structured approach, nurses help slow CKD progression and support effective patient care​.1. Comprehensive patient assessmentEffective management begins with nurses reviewing the patient’s medical history, and identifying key risk factors like diabetes, hypertension, and nephrotoxic drug use. Nurses assess signs of fluid...
Dialysis01:27

Dialysis

Renal failure occurs when the kidneys lose their ability to filter waste products from the blood effectively. It can be classified into two types: acute renal failure (ARF) and chronic renal failure (CRF).
Acute kidney injury develops suddenly and can be caused by pre-renal causes (e.g., hypovolemia, shock), intrinsic renal causes (e.g., acute tubular necrosis), or post-renal causes (e.g., urinary obstruction). In contrast, chronic renal failure progresses gradually over time and is often...
Dialysis01:15

Dialysis

Dialysis is a diffusion-based purification process that separates analyte molecules from a complex matrix. This is accomplished by allowing molecules in the solution to pass through a semipermeable membrane into a liquid on the other side. The membrane is usually made of cellulose acetate or cellulose nitrate, and the second liquid must be miscible with the solution. Ions (e.g., chloride or sodium) or organic molecules (e.g., glucose) can pass through the membrane pores, which generally have...
Chronic Kidney Disease I: Introduction01:25

Chronic Kidney Disease I: Introduction

Chronic Kidney Disease (CKD) arises when the kidneys progressively lose their ability to function, ultimately leading to end-stage renal disease. At this advanced stage, the kidneys can no longer filter waste or maintain essential body functions, requiring renal replacement therapy (RRT) through dialysis or a kidney transplant for survival.Early-stage chronic kidney disease and detection challengesIn CKD's early stages, symptoms often remain absent because healthy nephrons compensate for...

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5/6 Nephrectomy Using Sharp Bipolectomy Via Midline Laparotomy in Rats
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Voice in chronic renal failure.

Radish B Kumar1, Jayashree S Bhat

  • 1Department of Audiology and Speech Language Pathology, Kasturba Medical College, Mangalore, Karnataka, India. radheesh_b@yahoo.co.in

Journal of Voice : Official Journal of the Voice Foundation
|October 9, 2009
PubMed
Summary

Patients with chronic renal failure exhibit significant vocal changes. This study reveals voice deviations in acoustic and aerodynamic measures, impacting speech in these individuals.

Area of Science:

  • Nephrology
  • Speech-Language Pathology
  • Otolaryngology

Background:

  • Chronic renal failure (CRF) impacts multiple organ systems, including the respiratory system.
  • Respiratory compromise in CRF can lead to vocal dysfunctions due to its role in speech production.

Purpose of the Study:

  • To investigate acoustic and aerodynamic voice characteristics in patients with chronic renal failure.
  • To identify potential vocal changes associated with the pathophysiology of CRF.

Main Methods:

  • Acoustic analysis of sustained vowel /a/ using VAGHMI software.
  • Aerodynamic analysis of sustained phonation of /a/, /s/, and /z/.
  • Independent t-test for statistical comparison between CRF patients and healthy subjects.

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Assessment of Vascular Function in Patients With Chronic Kidney Disease
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Assessment of Vascular Function in Patients With Chronic Kidney Disease

Published on: June 16, 2014

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5/6 Nephrectomy Using Sharp Bipolectomy Via Midline Laparotomy in Rats
05:34

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Published on: April 4, 2025

Assessment of Vascular Function in Patients With Chronic Kidney Disease
08:50

Assessment of Vascular Function in Patients With Chronic Kidney Disease

Published on: June 16, 2014

Main Results:

  • Significant deviations in frequency and perturbation measures were observed in CRF subjects.
  • Aerodynamic measures also showed significant differences between CRF patients and the control group.
  • These findings indicate measurable vocal alterations in individuals with chronic renal failure.

Conclusions:

  • Chronic renal failure is associated with significant changes in voice acoustics and aerodynamics.
  • These vocal dysfunctions may stem from the underlying pathophysiology of CRF affecting respiratory function.
  • Further research is warranted to explore the clinical implications and management of these voice changes.