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Updated: Jun 19, 2026

Functionalized Spirocyclic Heterocycle Synthesis and Cytotoxicity Assay
Published on: February 9, 2021
Synthesis and antimicrobial studies of s-triazine based heterocycles
Dharmendra H Patel1, Kishor H Chikhalia, Nisha K Shah
1Department of Chemistry, School of Sciences, Gujarat University, Ahmadabad, Gujarat, India. dharmendrah1@gmail.com
Abstract:
In an effort to discover new candidates with improved antimicrobial activities we report here the synthesis and in vitro biological evalution of various series of 2-(N-methylamino)-4-(N,N-dimethylamino)-6-(arylthioureido)-s-triazine (5a-j) and (N-methylamino)-4-(N,N-dimethylamino)-6-(arylureido)-s-triazine (6a-j). All the synthesized compounds were screened in vitro for their antibacterial activity against two different gram-positive bacteria (S. aureus, B. subtilis) and two different gram-negative bacteria (P. aeruginosa, E. coli) using the broth dilution method.
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