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Related Concept Videos

Angle Closure Glaucoma: Treatment01:28

Angle Closure Glaucoma: Treatment

Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
Glaucoma: Overview01:25

Glaucoma: Overview

Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
Open Angle Glaucoma: Treatment01:27

Open Angle Glaucoma: Treatment

In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...

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Related Experiment Video

Updated: Jun 19, 2026

Quantification of Optic Nerve Cross Sectional Area on MRI: A Novel Protocol using Fiji Software
08:57

Quantification of Optic Nerve Cross Sectional Area on MRI: A Novel Protocol using Fiji Software

Published on: September 4, 2021

Quantitative iris parameters and association with narrow angles.

Bingsong Wang1, Lisandro M Sakata, David S Friedman

  • 1Singapore Eye Research Institute and Singapore National Eye Center, Singapore.

Ophthalmology
|October 10, 2009
PubMed
Summary
This summary is machine-generated.

Quantitative iris measurements like curvature, area, and thickness are linked to narrow angles. These iris parameters are especially associated with narrow angles in women and older individuals, offering insights into angle closure.

Related Experiment Videos

Last Updated: Jun 19, 2026

Quantification of Optic Nerve Cross Sectional Area on MRI: A Novel Protocol using Fiji Software
08:57

Quantification of Optic Nerve Cross Sectional Area on MRI: A Novel Protocol using Fiji Software

Published on: September 4, 2021

Area of Science:

  • Ophthalmology
  • Anatomy
  • Medical Imaging

Background:

  • Narrow angles are a risk factor for angle-closure glaucoma.
  • Understanding the anatomical factors contributing to narrow angles is crucial for early detection and prevention.
  • Previous studies have explored various risk factors, but quantitative iris morphology has not been extensively investigated.

Purpose of the Study:

  • To investigate the relationship between quantitative iris parameters, including iris curvature (I-Curv), iris area (I-Area), and iris thickness, and the presence of narrow angles.
  • To determine if specific iris measurements can predict the likelihood of having narrow angles.

Main Methods:

  • A cross-sectional, community-based study involving 2047 subjects over 50 years old.
  • Gonioscopy and anterior segment optical coherence tomography (AS-OCT) were performed under dark conditions.
  • Customized software measured I-Curv, I-Area, and iris thickness (IT750, IT2000) from AS-OCT scans.

Main Results:

  • Of 1465 analyzed eyes, 21.5% had narrow angles.
  • Significantly greater mean I-Curv, IT750, and IT2000 were observed in subjects with narrow angles.
  • Increased I-Curv, I-Area, IT750, and IT2000 were independently associated with narrow angles, with odds ratios ranging from 2.5 to 2.7.
  • Stronger associations were found in women and subjects aged 60 years and older.

Conclusions:

  • Quantitative iris parameters (I-Curv, I-Area, iris thickness) are independently associated with narrow angles.
  • These findings are particularly pronounced in women and older individuals.
  • The study provides valuable insights into the pathogenesis of angle closure in the Singaporean population.