In vivo assessment of Berger's space in primary angle closure disease using AS-OCT: a comparative study

Area of Science:

• Ophthalmology
• Anatomic Studies
• Glaucoma Research

Background:

• Primary angle closure disease (PACD) is a significant cause of vision loss.
• Berger's space, a potential anatomical landmark, has not been extensively studied in vivo in PACD.
• Understanding its visibility may offer insights into PACD pathophysiology.

Purpose of the Study:

• To visualize Berger's space in eyes with primary angle closure disease (PACD) using in vivo imaging.
• To identify demographic and ocular biometric factors associated with Berger's space visibility in PACD.

Main Methods:

• A cross-sectional observational study involving 81 participants (109 eyes) with PACD.
• Anterior segment optical coherence tomography (AS-OCT) was utilized for Berger's space evaluation.
• Ocular biometric parameters were measured, and comparisons were made between different PACD subtypes and visibility groups.

Main Results:

• The prevalence of visible Berger's space was highest in acute primary angle closure (APAC) at 36.67%.
• Eyes with visible Berger's space were characterized by younger age, narrower anterior chamber angles, and anterior lens shift.
• Acute angle closure (OR=5.650) and younger age (OR=0.937) were significantly associated with visible Berger's space.

Conclusions:

• Acute angle closure and younger age are key factors linked to increased Berger's space visibility in PACD.
• Visible Berger's space in PACD correlates with specific anatomical features like narrower angles and anterior lens positioning.