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Updated: Jun 19, 2026

A Modified Method for Heterotopic Mouse Heart Transplantion
Published on: June 23, 2014
Three strikes--don't die of a broken heart
Mark L Field1, Priya Sastry, David Richens
1The Liverpool Heart and Chest Hospital, Liverpool, UK. mlfield@doctors.net.uk
Abstract:
There are multiple layers of complexity in prevention of vehicle related blunt traumatic aortic rupture (BTAR), many of which are enshrined within government policy and car design. We present a 'layers of protection analysis' (LOPA) based loosely on original work by Professor John Doyle, which describes these attempts to 'design out' the risk of BTAR following a vehicle collision. We have modified this approach to include a physiological dimension suggesting that this may be a factor in susceptibility to aortic injury following trauma. Understanding processes involved in BTAR following vehicle collisions is key to designing preventative processes.
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