Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Genomic Imprinting and Inheritance

Genomic Imprinting and Inheritance

Diploid organisms inherit genetic material through chromosomes from both parents. Copies of the same gene are known as alleles. In most cases, both alleles are simultaneously expressed and allow various cellular processes to function optimally. If one of the alleles is missing or mutated, the expression of the other allele can compensate; however, this is not true for all genes.
The expression of some genes depends on which parent passed the gene to the offspring, through a phenomenon known as...

Teratogenicity

Teratogenicity

The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...

Human Genetics

Human Genetics

Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...

Mutations

Mutations

Mutations

Mutations

Mutations are changes in the sequence of DNA. These changes can occur spontaneously or they can be induced by exposure to environmental factors. Mutations can be characterized in a number of different ways: whether and how they alter the amino acid sequence of the protein, whether they occur over a small or large area of DNA, and whether they occur in somatic cells or germline cells.
Chromosomal Alterations Are Large-Scale Mutations
While point mutations are changes in a single nucleotide in...

Mutations

Mutations

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Single cell spatial transcriptomics links Wnt signaling disruption to extracellular matrix development in a cleft palate model.

Scientific reports·2025

Same author

Partners in African Cleft Training (PACT): Evolution of a Partnership Supporting Sustainable Interdisciplinary Cleft Team Care in Sub-Saharan Africa.

The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association·2025

Same author

Single Cell Spatial Transcriptomics of the Murine Embryonic Palate Links Pax9 to Patterning and Organization of Extracellular Matrix Components.

Research square·2025

Same author

An Exploratory Analysis of Early Care Differences and Risk of Post-Maxillary Advancement VPI in Individuals With Cleft Palate.

The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association·2025

Same author

Does Surgical Sequencing Influence the Accuracy of Maxillary Positioning in Bimaxillary Cleft Orthognathic Surgery?

Plastic and reconstructive surgery·2024

Same author

Discussion: Comparative Assessment of Orthodontic and Aesthetic Outcomes after Orthognathic Surgery with Clear Aligner or Fixed Appliance Therapy.

Plastic and reconstructive surgery·2024

Same journal

Pharyngeal Airway Changes Following Bimaxillary Orthognathic Surgery in Asian Patients.

The Journal of craniofacial surgery·2026

Same journal

Endoscopic Transcaruncular Approach for Early Anterior Ethmoidal Artery Cauterization in Large Olfactory Groove Meningioma Surgery: Intraoperative Video.

The Journal of craniofacial surgery·2026

Same journal

Clinical Manifestation of Congenital Unilateral Lower Lip Palsy: A Study of 111 Patients.

The Journal of craniofacial surgery·2026

Same journal

Racial and Regional Differences of the Cheek for Facial Feminization: A Systematic Review.

The Journal of craniofacial surgery·2026

Same journal

A Comparative Study Between the Modified Septal Extension Graft Based on the L-Strut Septum and the Costal Cartilage Graft Based on an Intact Native Septum in Nasal Plasty.

The Journal of craniofacial surgery·2026

Same journal

Does Angular Sagittal Split Osteotomy of the Mandibular Ramus Alter Fracture Patterns Compared With the Modifications of Posnick, Wolford, and Hunsuck/Epker?

The Journal of craniofacial surgery·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Jun 19, 2026

A Novel Strategy Combining Array-CGH, Whole-exome Sequencing and In Utero Electroporation in Rodents to Identify Causative Genes for Brain Malformations

A Novel Strategy Combining Array-CGH, Whole-exome Sequencing and In Utero Electroporation in Rodents to Identify Causative Genes for Brain Malformations

Published on: December 1, 2017

Genetics and human malformations.

Gabriele Mues¹, Hitesh Kapadia, Ying Wang

¹Department of Biomedical Sciences, Texas A&M University Health Science Center Baylor College of Dentistry, Dallas, Texas 75246, USA.

The Journal of Craniofacial Surgery

|October 10, 2009

Summary

This summary is machine-generated.

Genetic research is advancing healthcare, particularly in craniofacial surgery and dentistry. Understanding genes like PAX9, MSX1, AXIN2, and EDA aids in diagnosing and treating tooth agenesis.

More Related Videos

Using Mouse Oocytes to Assess Human Gene Function During Meiosis I

Using Mouse Oocytes to Assess Human Gene Function During Meiosis I

Published on: April 10, 2018

Understanding Cerebellar Pattern Formation

Understanding Cerebellar Pattern Formation

Published on: November 1, 2007

Related Experiment Videos

Last Updated: Jun 19, 2026

A Novel Strategy Combining Array-CGH, Whole-exome Sequencing and In Utero Electroporation in Rodents to Identify Causative Genes for Brain Malformations

A Novel Strategy Combining Array-CGH, Whole-exome Sequencing and In Utero Electroporation in Rodents to Identify Causative Genes for Brain Malformations

Published on: December 1, 2017

Using Mouse Oocytes to Assess Human Gene Function During Meiosis I

Using Mouse Oocytes to Assess Human Gene Function During Meiosis I

Published on: April 10, 2018

Understanding Cerebellar Pattern Formation

Understanding Cerebellar Pattern Formation

Published on: November 1, 2007

Area of Science:

Genetics and Molecular Biology
Craniofacial Surgery
Dentistry

Background:

Genetics is increasingly vital in healthcare, impacting craniofacial surgery and dentistry.
Genetic advances offer progress in understanding, diagnosing, and treating various health issues.

Purpose of the Study:

To review the roles of specific genes in congenital tooth agenesis.
To highlight the potential of molecular genetics in improving patient care for dental anomalies.

Main Methods:

Literature review on genetic factors in tooth agenesis.
Focus on the PAX9, MSX1, AXIN2, and EDA genes.

Main Results:

These genes are implicated in the causation of congenital tooth agenesis.
Molecular genetic research shows promise for enhanced patient management.

Conclusions:

Understanding the genetic basis of tooth agenesis is crucial for advancing craniofacial and dental care.
Further molecular genetic research will likely lead to improved diagnostic and therapeutic strategies.