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Phosphorylation by protein kinase C modulates agonist binding to striatal dopamine D2 receptors
P Rogue1, J Zwiller, A N Malviya
1Centre de Neurochimie du C.N.R.S., Strasbourg, France.
Biochemistry International
|November 1, 1990
Abstract:
The effect of purified protein kinase C (PKC) on dopamine D2 receptor binding was studied. Saturation binding with [3H]spiperone was not affected. In competition experiments using agonists PKC-treated membranes showed a significant reduction in the proportion of high affinity sites, and the influence of GTP gamma S was abolished. These results suggest that PKC-dependent mechanisms can regulate the coupling between the dopamine D2 receptor and its G-protein.