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Updated: Jun 19, 2026

A Simple Bioassay for the Evaluation of Vascular Endothelial Growth Factors
Published on: March 15, 2016
VEGF -460C>T polymorphism and cancer risk: a meta-analysis
Bin Xu1, Ning-Han Feng, Na Tong
1Department of Urology, First Affiliated Hospital of Nanjing Medical University, 300 Guangzhou Road, 210029, Nanjing, China. xb15896450810@126.com
Abstract:
Vascular endothelial growth factor (VEGF) is a major driver of physiological and pathological angiogenesis and plays important roles in the etiology and metastasis of cancers. The -460C>T polymorphism in VEGF gene region has been implicated in cancer risk and related to VEGF expression. However, published data remain conflicting. To derive a more precise estimation, a meta-analysis of 5,863 cases and 5,276 controls from 14 published case-control studies was performed. Odds ratios (ORs) with 95% confidence intervals (CIs) were estimated to assess the association. VEGF -460T represented a risk factor for cancers in Asians (OR=1.69, 95% CI: 1.09-2.62) but not in Europeans (OR=0.92, 95% CI: 0.78-1.08). Our meta-analysis showed the evidence that VEGF -460T was associated with increased cancer risk in Asians. Further prospective researches with larger numbers of worldwide participants are expected to validate this result.
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