Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Plastic Behavior01:21

Plastic Behavior

A material's elastic behavior is characterized by the disappearance of stress once the load is removed, allowing the material to return to its original state. However, when stress surpasses the yield point, yielding commences, marking the onset of plastic deformation or permanent set. This change from elastic to plastic behavior is influenced by the peak stress value and the duration before the load is removed. An intriguing observation occurs when a specimen is loaded, unloaded, and reloaded.
Relation between Poisson's ratio, Modulus of Elasticity and Modulus of Rigidity01:15

Relation between Poisson's ratio, Modulus of Elasticity and Modulus of Rigidity

Deformation occurs in axial and transverse directions when an axial load is applied to a slender bar. This deformation impacts the cubic element within the bar, transforming it into either a rectangular parallelepiped or a rhombus, contingent on its orientation. This transformation process induces shearing strain. Axial loading elicits both shearing and normal strains. Applying an axial load instigates equal normal and shearing stresses on elements oriented at a 45° angle to the load axis.
Residual Stresses in Bending01:18

Residual Stresses in Bending

In the study of elastoplastic members subjected to bending moments, understanding the loading and unloading phases is crucial for assessing material behavior and structural integrity. During the loading phase, as the bending moment increases, the material initially responds elastically, adhering to Hooke's Law, where stress is directly proportional to strain. When the load exceeds the yield strength, plastic deformation occurs, resulting in permanent strain and deformation that remains even...
Plastic Deformations01:19

Plastic Deformations

Plastic deformation represents a fundamental concept in materials science, which explains the irreversible change in the shape of a material when it experiences stress beyond its elastic capability. This phenomenon is important in structural engineering, especially in designing and analyzing cantilever beams—structures that are securely fixed at one end and bear loads at the opposite end. When these beams are subjected to loads within their elastic range, they will return to their original...
Plastic Deformations01:14

Plastic Deformations

It is essential to understand how structural members behave under plastic deformation when the bending stress exceeds the material's yield strength. This state of deformation permanently alters the shape of the member, in contrast to the linear elastic behavior observed before yielding. The strain at any point in the member is expressed in terms of maximum strain. Notably, the neutral axis, which coincides with the centroid during elastic bending, shifts away from the centroid under plastic...
Deformation of Member under Multiple Loadings01:11

Deformation of Member under Multiple Loadings

When a rod is made of different materials or has various cross-sections, it must be divided into parts that meet the necessary conditions for determining the deformation. These parts are each characterized by their internal force, cross-sectional area, length, and modulus of elasticity. These parameters are then used to compute the deformation of the entire rod.
In the case of a member with a variable cross-section, the strain is not constant but depends on the position. The deformation of an...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Prediction of Large-Scale Adsorption Process Parameters Using Two-Mechanism Langmuir Constants.

Pharmaceutical research·2026
Same author

Explaining the underlying causes of different tabletability classifications of binary mixtures.

Journal of pharmaceutical sciences·2026
Same author

Chewable Tablets for Precise Unit Dosing of Animals.

Journal of pharmaceutical innovation·2026
Same author

Call for Manuscript Submissions to the Thomas Rades Dedicated Issue.

Journal of pharmaceutical sciences·2025
Same author

Comparing the applicability of mixing rules to predict the tensile strength of compacted mixtures.

Journal of pharmaceutical sciences·2025
Same author

Interaction-Based Model to Predict Tensile Strength of Compacted Mixtures from Individual Component Data.

Molecular pharmaceutics·2025

Related Experiment Video

Updated: Jun 19, 2026

Stress Distribution During Cold Compression of Rocks and Mineral Aggregates Using Synchrotron-based X-Ray Diffraction
10:36

Stress Distribution During Cold Compression of Rocks and Mineral Aggregates Using Synchrotron-based X-Ray Diffraction

Published on: May 20, 2018

Interpreting deformation behavior in pharmaceutical materials using multiple consolidation models and compaction

Ira S Buckner1, Dale Eric Wurster, Aktham Aburub

  • 1College of Pharmacy; University of Iowa; Iowa City, IA, USA. buckneri@duq.edu

Pharmaceutical Development and Technology
|October 13, 2009
PubMed
Summary

A combined approach using multiple consolidation models and mechanical energy analysis offers a more reliable method for evaluating pharmaceutical material plasticity and identifying complex behaviors during tableting. This enhances understanding of material deformation mechanisms.

More Related Videos

A Coupled Experiment-finite Element Modeling Methodology for Assessing High Strain Rate Mechanical Response of Soft Biomaterials
11:28

A Coupled Experiment-finite Element Modeling Methodology for Assessing High Strain Rate Mechanical Response of Soft Biomaterials

Published on: May 18, 2015

Studying Large Amplitude Oscillatory Shear Response of Soft Materials
06:07

Studying Large Amplitude Oscillatory Shear Response of Soft Materials

Published on: April 25, 2019

Related Experiment Videos

Last Updated: Jun 19, 2026

Stress Distribution During Cold Compression of Rocks and Mineral Aggregates Using Synchrotron-based X-Ray Diffraction
10:36

Stress Distribution During Cold Compression of Rocks and Mineral Aggregates Using Synchrotron-based X-Ray Diffraction

Published on: May 20, 2018

A Coupled Experiment-finite Element Modeling Methodology for Assessing High Strain Rate Mechanical Response of Soft Biomaterials
11:28

A Coupled Experiment-finite Element Modeling Methodology for Assessing High Strain Rate Mechanical Response of Soft Biomaterials

Published on: May 18, 2015

Studying Large Amplitude Oscillatory Shear Response of Soft Materials
06:07

Studying Large Amplitude Oscillatory Shear Response of Soft Materials

Published on: April 25, 2019

Area of Science:

  • Pharmaceutical Sciences
  • Materials Science
  • Chemical Engineering

Background:

  • Tableting behavior is typically assessed qualitatively.
  • Quantitative methods use consolidation models to determine material deformation mechanisms.

Purpose of the Study:

  • To present a reliable method for evaluating pharmaceutical material plasticity.
  • To identify complicating behaviors during tableting using a concerted approach.

Main Methods:

  • Collected force-displacement, porosity-pressure, and tensile strength data using a single instrument.
  • Analyzed porosity and tensile strength data with new and classical consolidation models.
  • Interpreted model predictions using mechanical work measurements.

Main Results:

  • A concerted approach with multiple models and mechanical energy analysis provides a more reliable evaluation of material plasticity.
  • Disagreement between model predictions indicates atypical behavior requiring further investigation.
  • Work energy from compression/decompression supports plasticity assessment.

Conclusions:

  • Diverse consolidation models, when in agreement, increase confidence in plasticity evaluation.
  • Mechanical energy analysis is crucial for interpreting consolidation model predictions and identifying anomalies.
  • The study supports using work energy as an initial measure of plasticity in pharmaceutical materials.