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Updated: Jun 19, 2026
12:37
Pharmacologic Induction of Epidermal Melanin and Protection Against Sunburn in a Humanized Mouse Model
Published on: September 7, 2013
A bioactive complex to protect proteins from UV-induced oxidation in human epidermis
K Schweikert1, F Gafner, G Dell'Acqua
1Induchem AG, Industriestrasse 8, 8604 Volketswil.
International Journal of Cosmetic Science
|October 13, 2009
Summary
A new bioactive complex combats UV-induced skin damage by preventing protein oxidation and supporting repair enzymes. This offers protection against photo-ageing, dehydration, and age spots.
Area of Science:
- Dermatology
- Biochemistry
- Cosmetic Science
Background:
- UV radiation causes skin damage via protein oxidation.
- Accumulation of oxidized proteins contributes to skin ageing, elastosis, and pigmentation.
- Proteasome activity and protective enzyme function decline with age, exacerbating damage.
Purpose of the Study:
- To investigate a bioactive complex of Panthenyl triacetate and Ethyl linoleate for combating UV-induced protein oxidation.
- To evaluate the complex's efficacy in protecting against UV damage and supporting skin repair mechanisms.
Main Methods:
- Testing a 3% concentration of the bioactive complex on human skin biopsies.
- Assessing protection against UV (UVA + UVB)-induced protein oxidation via pre- and post-irradiation treatments.
- Measuring the impact of the complex on mRNA expression of protein repairing enzymes, specifically Methionine Sulfoxide Reductase (MSR).
Main Results:
- The complex demonstrated significant protection against UV-induced protein oxidation (72% pre-treatment, 78% post-treatment).
- UV irradiation decreased mRNA for protein repairing enzymes like MSR.
- The bioactive complex stimulated the expression of these essential repairing enzymes.
Conclusions:
- The bioactive complex effectively prevents UV-induced protein oxidation in human skin.
- It supports the expression of crucial protein repairing enzymes, counteracting UV-induced downregulation.
- This complex shows potential for preventing skin photo-ageing, dehydration, elastosis, and age spot formation.
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