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Related Concept Videos

Cancer Stem Cells and Tumor Maintenance02:40

Cancer Stem Cells and Tumor Maintenance

Early diagnosis and treatment can often cure cancer. However, even with treatment, residual cells called cancer stem cells (CSC) might remain, often causing tumor recurrence. These cancer stem cells possess the potential for self-renewal and multi-lineage differentiation and are often responsible for the therapeutic resistance displayed in most cancers.
Cancer stem cells are thought to originate from tissue-specific normal stem cells or progenitor cells. The normal stem cells usually reside in...
Cancer Stem Cells and Tumor Maintenance02:40

Cancer Stem Cells and Tumor Maintenance

Early diagnosis and treatment can often cure cancer. However, even with treatment, residual cells called cancer stem cells (CSC) might remain, often causing tumor recurrence. These cancer stem cells possess the potential for self-renewal and multi-lineage differentiation and are often responsible for the therapeutic resistance displayed in most cancers.
Cancer stem cells are thought to originate from tissue-specific normal stem cells or progenitor cells. The normal stem cells usually reside in...
Adaptive Mechanisms in Cancer Cells02:53

Adaptive Mechanisms in Cancer Cells

Cancer cells accumulate genetic changes at an abnormally rapid rate due to the defects in the DNA repair mechanisms. From an evolutionary perspective, such genetic instability is advantageous for cancer development. Mutant cell lines accumulate a series of beneficial mutations that contribute to their progression into cancer.
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...
Mechanism of Angiogenesis01:10

Mechanism of Angiogenesis

Blood vessel formation starts early during embryonic development, around day 7. In the extraembryonic yolk sac, mesodermal precursor cells called hemangioblast proliferate and differentiate into angioblast. Angioblasts express vascular endothelial growth factor receptor 2 or VEGFR2, which binds VEGF-A, a proangiogenic factor, guiding blood vessel formation. VEGF signaling promotes angioblasts to form a blood island in the developing embryo. Angioblasts further differentiate, giving rise to...
Regulation of Angiogenesis and Blood Supply01:24

Regulation of Angiogenesis and Blood Supply

Rapidly dividing tumors, embryos, and wounded tissues require more oxygen than usual, lowering the oxygen concentration in the blood. At low oxygen or hypoxic conditions, an oxygen-sensitive transcription factor called the hypoxia-inducible factor 1 or HIF1 is activated. HIF1 is a dimeric protein of alpha (ɑ) and beta (β) subunits.  Under optimal oxygen conditions, HIF1β is present in the nucleus while HIF1ɑ remains in the cytosol. HIF1ɑ is hydroxylated by prolyl hydroxylase and factor...
Distinctive Features of Adult Stem Cells vs Cancer Stem Cells01:18

Distinctive Features of Adult Stem Cells vs Cancer Stem Cells

A stem cell is an unspecialized cell that can divide without limit as needed and can, under specific conditions, differentiate into specialized cells.
Adult stem cells
Adult stem cells are tissue-specific; hence, they divide to develop the tissue from which they originate. One type of adult stem cell is the epithelial stem cell, which gives rise to the keratinocytes in the multiple layers of epithelial cells in the epidermis of the skin. Adult bone marrow has three distinct types of stem cells:...

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Related Experiment Video

Updated: Jun 19, 2026

Evaluating the Angiogenetic Properties of Ovarian Cancer Stem-Like Cells using the Three-Dimensional Co-Culture System, NICO-1
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Cancer stem cells and angiogenesis.

Rolf Bjerkvig1, Mikael Johansson, Hrvoje Miletic

  • 1NorLux Neuro-Oncology, Department of Biomedicine, University of Bergen, N-5009, Bergen, Norway. rolf.bjerkvig@biomed.uib.no

Seminars in Cancer Biology
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PubMed
Summary

Cancer stem-like cells drive tumor growth and angiogenesis by altering glucose metabolism. Understanding these metabolic pathways is crucial for developing targeted cancer therapies.

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Last Updated: Jun 19, 2026

Evaluating the Angiogenetic Properties of Ovarian Cancer Stem-Like Cells using the Three-Dimensional Co-Culture System, NICO-1
07:59

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Isolation and Characterization of a Head and Neck Squamous Cell Carcinoma Subpopulation Having Stem Cell Characteristics
11:28

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Published on: May 11, 2016

Area of Science:

  • Oncology
  • Cancer Biology
  • Metabolic Pathways

Background:

  • Most cancers exhibit tumor cells with stem cell-like properties.
  • The origin and timing of cancer stem-like cell emergence in tumors remain unclear.
  • These cells are implicated in tumor progression and therapeutic resistance.

Purpose of the Study:

  • To explore the metabolic adaptations of cancer stem-like cells.
  • To investigate the role of glycolysis in cancer stem-like cell phenotype.
  • To identify potential therapeutic targets within these metabolic pathways.

Main Methods:

  • Analysis of metabolic pathways in cancer stem-like cells.
  • Investigation of glucose metabolism and its byproducts (pyruvate, lactate).
  • Assessment of mitochondrial function and mass in cancer stem-like cells.

Main Results:

  • Cancer stem-like cells exhibit increased glycolysis, converting glucose to lactate.
  • Mitochondrial metabolism and mass are decreased in these cells.
  • These metabolic shifts contribute to a migratory and angiogenesis-independent phenotype.

Conclusions:

  • Cancer stem-like cells utilize specific metabolic pathways, including enhanced glycolysis, to support their functions.
  • Targeting these anaerobic metabolic pathways presents a promising strategy for cancer treatment.
  • Further research is needed to differentiate these pathways from those in normal stem cells.