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Updated: Jun 19, 2026

An Automated Microscopic Scoring Method for the γ-H2AX Foci Assay in Human Peripheral Blood Lymphocytes
Published on: December 25, 2021
Non-targeted effects of ionizing radiation: implications for risk assessment and the radiation dose response profile
William F Morgan1, Marianne B Sowa
1Biological Sciences Division, Pacific Northwest National Laboratory, P.O. Box 999, MSIN P7-56, Richland, WA 99354, USA. wfmorgan@pnl.gov
Abstract:
Radiation risks at low doses remain a hotly debated topic. Recent experimental advances in our understanding of effects occurring in the progeny of irradiated cells, and/or the non-irradiated neighbors of irradiated cells (i.e., non-targeted effects associated with exposure to ionizing radiation), have influenced this debate. The goal of this document is to summarize the current status of this debate and speculate on the potential impact of non-targeted effects on radiation risk assessment and the radiation dose response profile.
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