Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Disorders of the Nervous Tissue01:28

Disorders of the Nervous Tissue

1.9K
Nervous tissue is a vital component of the human body's communication system, enabling us to perceive and respond to stimuli. However, like all other tissues, it is vulnerable to disorders and diseases that can significantly impact our neurological functioning.
Homeostatic Imbalances:
Alzheimer's disease manifests as a gradual decline in memory and cognitive abilities, attributed to the buildup of amyloid plaques and neurofibrillary tangles in the brain.
Parkinson's disease arises from the...
1.9K
Biological Effects of Radiation02:59

Biological Effects of Radiation

16.3K
All radioactive nuclides emit high-energy particles or electromagnetic waves. When this radiation encounters living cells, it can cause heating, break chemical bonds, or ionize molecules. The most serious biological damage results when these radioactive emissions fragment or ionize molecules. For example, α and β particles emitted from nuclear decay reactions possess much higher energies than ordinary chemical bond energies. When these particles strike and penetrate matter, they...
16.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Female reproductive dysfunction and transgenerational consequences following prolonged spaceflight exposure.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same author

Hyperdynamic microtubule-based structural changes in Monocyte-Derived-Neuronal-like cells from patients with schizophrenia.

Schizophrenia (Heidelberg, Germany)·2026
Same author

Mechanistic Effects of Environmental and Medical Low-Dose Radiation Exposure of the Lung.

Biomedicines·2026
Same author

Deleterious NKAP Mutations Are Associated with Musculoskeletal Abnormalities in Hemizygous Males and Skewed X Chromosome Inactivation in Heterozygous Females.

International journal of molecular sciences·2026
Same author

Astroimmunology: the effects of spaceflight and its associated stressors on the immune system.

Nature reviews. Immunology·2025
Same author

Immunological and Respiratory Effects in a Healthy Rodent Model after Inhalation of Low and Regulated Levels of Radon.

Radiation research·2025

Related Experiment Video

Updated: Oct 13, 2025

Coherence between Brain Cortical Function and Neurocognitive Performance during Changed Gravity Conditions
12:29

Coherence between Brain Cortical Function and Neurocognitive Performance during Changed Gravity Conditions

Published on: May 23, 2011

19.7K

Neuro-consequences of the spaceflight environment.

Siddhita D Mhatre1, Janani Iyer2, Stephanie Puukila3

  • 1Space Biosciences Division, NASA Ames Research Center, Moffett Field, CA, 94035, USA; KBR, Houston, TX, 77002, USA; COSMIAC Research Center, University of New Mexico, Albuquerque, NM, 87131, USA.

Neuroscience and Biobehavioral Reviews
|November 12, 2021
PubMed
Summary
This summary is machine-generated.

Astronaut health in deep space is critical. This review examines spaceflight risks like radiation and microgravity, and discusses countermeasures to protect brain and behavioral health on long missions.

Keywords:
Central nervous systemIsolationMicrogravityOxidative stress responseRadiationRodentsSpaceflight

More Related Videos

Assessment of Global Ocular Structure Following Spaceflight Using a Micro-Computed Tomography Micro-CT Imaging Method
09:11

Assessment of Global Ocular Structure Following Spaceflight Using a Micro-Computed Tomography Micro-CT Imaging Method

Published on: October 27, 2020

5.9K
Exploring the Effects of Spaceflight on Mouse Physiology using the Open Access NASA GeneLab Platform
11:08

Exploring the Effects of Spaceflight on Mouse Physiology using the Open Access NASA GeneLab Platform

Published on: January 13, 2019

12.5K

Related Experiment Videos

Last Updated: Oct 13, 2025

Coherence between Brain Cortical Function and Neurocognitive Performance during Changed Gravity Conditions
12:29

Coherence between Brain Cortical Function and Neurocognitive Performance during Changed Gravity Conditions

Published on: May 23, 2011

19.7K
Assessment of Global Ocular Structure Following Spaceflight Using a Micro-Computed Tomography Micro-CT Imaging Method
09:11

Assessment of Global Ocular Structure Following Spaceflight Using a Micro-Computed Tomography Micro-CT Imaging Method

Published on: October 27, 2020

5.9K
Exploring the Effects of Spaceflight on Mouse Physiology using the Open Access NASA GeneLab Platform
11:08

Exploring the Effects of Spaceflight on Mouse Physiology using the Open Access NASA GeneLab Platform

Published on: January 13, 2019

12.5K

Area of Science:

  • Space Medicine
  • Neuroscience
  • Human Physiology

Background:

  • Human space exploration, including NASA's Artemis missions, is extending beyond Low Earth Orbit (LEO).
  • Astronauts face significant health risks from spaceflight hazards such as ionizing radiation, microgravity, and isolation.
  • Ensuring crew brain and behavioral health is paramount for long-duration deep space missions.

Purpose of the Study:

  • To comprehensively review the neurobiological and neurobehavioral effects of spaceflight and its analogs.
  • To identify mechanisms underlying physiological responses controlled by the Central Nervous System (CNS).
  • To inform the development of countermeasures for maintaining astronaut health.

Main Methods:

  • Review of existing literature on spaceflight effects on humans and animals.
  • Analysis of ground-based spaceflight analogs (simulated weightlessness, social isolation, radiation).
  • Discussion of potential dietary and non-dietary countermeasures.

Main Results:

  • Spaceflight and its analogs induce significant neurobiological and neurobehavioral changes.
  • Understanding CNS responses is key to mitigating spaceflight-induced health issues.
  • Various countermeasures, including artificial gravity and antioxidants, show promise.

Conclusions:

  • Continued research is essential to ensure neural, sensorimotor, and cognitive functions are maintained during deep space missions.
  • Effective countermeasures are crucial to prevent adverse health outcomes and ensure mission success.
  • Proactive strategies are needed to safeguard astronaut well-being in extreme environments.