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Related Experiment Video

Updated: Jun 19, 2026

Network Pharmacology Prediction and Metabolomics Validation of the Mechanism of Fructus Phyllanthi against Hyperlipidemia
11:06

Network Pharmacology Prediction and Metabolomics Validation of the Mechanism of Fructus Phyllanthi against Hyperlipidemia

Published on: April 7, 2023

Artichoke leaf extract for treating hypercholesterolaemia.

Barbara Wider1, Max H Pittler, Joanna Thompson-Coon

  • 1Complementary Medicine, Peninsula Medical School, Universities of Exeter and Plymouth, 25 Victoria Park Road, Exeter, UK, EX2 4NT.

The Cochrane Database of Systematic Reviews
|October 13, 2009
PubMed
Summary
This summary is machine-generated.

Artichoke leaf extract (ALE) shows potential for lowering cholesterol levels in individuals with hypercholesterolaemia. However, current evidence is not yet convincing, with mild side effects reported in short-term use.

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Last Updated: Jun 19, 2026

Network Pharmacology Prediction and Metabolomics Validation of the Mechanism of Fructus Phyllanthi against Hyperlipidemia
11:06

Network Pharmacology Prediction and Metabolomics Validation of the Mechanism of Fructus Phyllanthi against Hyperlipidemia

Published on: April 7, 2023

Area of Science:

  • Cardiovascular Health
  • Phytotherapy
  • Evidence-Based Medicine

Background:

  • Hypercholesterolaemia significantly elevates the risk of coronary heart disease and atherosclerosis.
  • Artichoke leaf extract (ALE) is recognized for its potential cholesterol-lowering properties.
  • The efficacy of ALE for hypercholesterolaemia management remains under investigation.

Purpose of the Study:

  • To evaluate the effectiveness of Artichoke leaf extract (ALE) against placebo or standard treatments for hypercholesterolaemia.
  • To assess ALE's impact on total cholesterol levels in patients with elevated levels (≥5.17 mmol/L or 200 mg/dL).

Main Methods:

  • Systematic review of randomized controlled trials (RCTs) comparing ALE monopreparations with placebo or reference drugs.
  • Searched major databases (Cochrane, MEDLINE, EMBASE, AMED, CINAHL) up to June 2008.
  • Independent data extraction and quality assessment by two reviewers.

Main Results:

  • Three RCTs involving 262 participants were included.
  • ALE demonstrated a statistically significant reduction in total cholesterol levels in two trials.
  • One trial noted significant cholesterol reduction with ALE in a subgroup of patients with baseline levels >230 mg/dL.
  • Reported adverse events were mild, transient, and infrequent.

Conclusions:

  • Clinical trial data suggest Artichoke leaf extract (ALE) may help lower cholesterol.
  • The current evidence supporting ALE's efficacy for hypercholesterolaemia is not yet conclusive.
  • Short-term use of ALE appears to be associated with mild, infrequent adverse events.