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Burden of severe rotavirus diarrhea in indonesia

Yati Soenarto1, Abu T Aman, Achirul Bakri

  • 1Departments of Child Health, Faculty of Medicine, Gadjah Mada University, Sardjito Hospital, Yogyakarta.

The Journal of Infectious Diseases
|October 14, 2009
PubMed

Insights

Rotavirus is a major cause of severe diarrhea in Indonesian children, with high hospitalization rates. Most infections in children under two were linked to common G and P genotypes, suggesting vaccine effectiveness.

Area of Science:

  • Pediatrics
  • Infectious Diseases
  • Public Health

Background:

  • Rotavirus is a leading cause of severe diarrhea, hospitalizations, and deaths in children globally.
  • The disease burden of rotavirus in Indonesia remains poorly documented, hindering targeted public health interventions.

Purpose of the Study:

  • To determine the burden and characteristics of rotavirus disease among young children in Indonesia.
  • To identify common rotavirus genotypes circulating in Indonesia and assess their implications for vaccine efficacy.

Main Methods:

  • Prospective surveillance of children under 5 years with diarrhea was conducted at 6 hospitals across 6 Indonesian provinces.
  • Standardized methodology was used for rotavirus testing in both inpatient and outpatient settings.
  • Rotavirus strains were genotyped to identify common G and P types.

Main Results:

  • Rotavirus was detected in 60% of hospitalized children and 41% of outpatient children with diarrhea.
  • Dehydration and vomiting were significantly more common in rotavirus-positive cases.
  • Children aged 6-23 months accounted for 72% of rotavirus episodes.
  • The most prevalent genotypes were G9 (30%) and P[6] (56%), with G1P[6] and G9P[6] being common combinations.

Conclusions:

  • Rotavirus infection poses a significant burden on Indonesian children, particularly those aged 6-23 months.
  • The common circulating genotypes G9 and P[6] suggest that current rotavirus vaccines are likely to be efficacious.
  • Continued surveillance of rotavirus genotypes is essential to monitor for uncommon strains and potential changes in epidemiology.

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