Recovery following propofol-associated brugada electrocardiogram

Area of Science:

• Cardiology
• Clinical Medicine
• Pharmacology

Background:

• Brugada syndrome is a genetic disorder linked to sudden cardiac death, characterized by distinct electrocardiographic (ECG) patterns.
• Recent reports suggest Brugada ECG patterns can emerge in critically ill patients administered propofol, correlating with elevated mortality.
• The underlying mechanisms linking propofol to Brugada ECG patterns in critically ill patients require further investigation.

Observation:

• This case report details a critically ill patient who exhibited a Brugada ECG pattern after receiving high-dose propofol infusion.
• The patient's clinical status and ECG findings were closely monitored during propofol administration.
• The development of the Brugada ECG pattern was directly observed following the initiation of high-dose propofol therapy.

Findings:

• The Brugada ECG pattern in this critically ill patient resolved upon discontinuation of propofol.
• Prompt recognition and cessation of propofol led to the resolution of the Brugada ECG pattern.
• The patient experienced no subsequent arrhythmic complications and was discharged in stable condition.

Implications:

• This case underscores the potential for propofol to induce Brugada ECG patterns, particularly in critically ill individuals.
• Awareness of this association is crucial for clinicians managing critically ill patients receiving propofol, necessitating vigilant ECG monitoring.
• Early recognition and management, including propofol withdrawal, can mitigate risks and prevent adverse cardiac events.