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Related Experiment Video

Updated: Jun 19, 2026

Multifocal Electroretinograms

Multifocal Electroretinograms

Published on: December 4, 2011

Features and function of multiple evanescent white dot syndrome.

Masanori Hangai¹, Masahiro Fujimoto, Nagahisa Yoshimura

¹Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, 54 Kawahara-cho, Shogoin, Sakyo-ku, Kyoto 606-8507, Japan. hangai@kuhp.kyoto-u.ac.jp

Archives of Ophthalmology (Chicago, Ill. : 1960)

|October 14, 2009

Summary

Multiple evanescent white dot syndrome (MEWDS) shows specific photoreceptor layer abnormalities on enhanced spectral-domain optical coherence tomography (SD-OCT). These tomographic and functional changes shift location during recovery.

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Area of Science:

Ophthalmology
Medical Imaging
Retinal Diseases

Background:

Multiple evanescent white dot syndrome (MEWDS) is an inflammatory condition affecting the outer retina.
Understanding its tomographic features and macular abnormalities is crucial for diagnosis and management.

Purpose of the Study:

To describe and compare the tomographic features and macular abnormalities of MEWDS throughout its clinical course.
To correlate imaging findings with functional deficits.

Main Methods:

Five patients with characteristic MEWDS lesions were studied.
Enhanced spectral-domain optical coherence tomography (SD-OCT), indocyanine green angiography (IA), and microperimetric retinal sensitivity examination were utilized.
Imaging and functional tests were performed at diagnosis and during follow-up until resolution.

Main Results:

Enhanced SD-OCT identified focal lesions in the outer photoreceptor layer with disrupted inner and outer segment junctions, correlating with IA hypofluorescence.
Areas of reduced retinal sensitivity on microperimetry matched SD-OCT findings of inner/outer segment junction disruption.
A temporal shift of these abnormalities from the optic disc to the macula was observed within the first month, with near-normal recovery around one month post-diagnosis.

Conclusions:

Enhanced SD-OCT reveals photoreceptor layer abnormalities specific to MEWDS.
These tomographic and functional changes exhibit dynamic spatial changes during clinical recovery from MEWDS.