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The effect of cigarette smoke on the plasma piroxicam concentrations in rats
F Lermioğlu1, T Berkan, M Yasa
1Department of Pharmacology, Faculty of Pharmacy, Ege University, Izmir, Turkey.
The Journal of Pharmacy and Pharmacology
|November 1, 1990
Abstract:
The plasma concentration of unchanged piroxicam has been determined at 15, 30, 60 and 90 min after 10 mg kg-1 oral administration of the drug to rats exposed to cigarette smoke or pretreated with phenobarbitone, 3,4-benzpyrene or ethanol. Plasma piroxicam concentrations decreased in rats pretreated with phenobarbitone, 3,4-benzpyrene and ethanol and in rats 24 h after exposure to cigarette smoke.