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Related Experiment Video

Updated: Jun 19, 2026

Microfluidic Buffer Exchange for Interference-free Micro/Nanoparticle Cell Engineering
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Microfluidic Buffer Exchange for Interference-free Micro/Nanoparticle Cell Engineering

Published on: July 10, 2016

Inertial microfluidics.

Dino Di Carlo1

  • 1Department of Bioengineering and California NanoSystems Institute, Henry Samueli School of Engineering and Applied Science, University of California, Los Angeles, CA 90095, USA. dicarlo@seas.ucla.edu

Lab on a Chip
|October 14, 2009
PubMed
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Fluid inertia, often overlooked in microfluidics, drives key applications like particle separation and bioparticle focusing. Inertial microfluidic systems offer robust, high-throughput solutions for diagnostics and environmental cleanup.

Area of Science:

  • Fluid Dynamics
  • Microfluidics
  • Biotechnology

Background:

  • Common wisdom suggests fluid inertia is negligible in microfluidic phenomena.
  • Recent research demonstrates significant microfluidic effects driven by fluid inertia.

Purpose of the Study:

  • To review recent progress in inertial microfluidic systems.
  • To clarify the fundamental fluid dynamic effects exploited in these systems.
  • To suggest future research directions for microscale fluid inertia.

Main Methods:

  • Discussion of prototype inertial microfluidic systems.
  • Analysis of fluid dynamic principles governing inertial effects.
  • Review of applications in particle separation, mixing, and bioparticle focusing.

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Label-free Neutrophil Enrichment from Patient-derived Airway Secretion Using Closed-loop Inertial Microfluidics
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High Speed Droplet-based Delivery System for Passive Pumping in Microfluidic Devices
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High Speed Droplet-based Delivery System for Passive Pumping in Microfluidic Devices

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Last Updated: Jun 19, 2026

Microfluidic Buffer Exchange for Interference-free Micro/Nanoparticle Cell Engineering
10:27

Microfluidic Buffer Exchange for Interference-free Micro/Nanoparticle Cell Engineering

Published on: July 10, 2016

Label-free Neutrophil Enrichment from Patient-derived Airway Secretion Using Closed-loop Inertial Microfluidics
07:37

Label-free Neutrophil Enrichment from Patient-derived Airway Secretion Using Closed-loop Inertial Microfluidics

Published on: June 7, 2018

High Speed Droplet-based Delivery System for Passive Pumping in Microfluidic Devices
10:22

High Speed Droplet-based Delivery System for Passive Pumping in Microfluidic Devices

Published on: September 2, 2009

Main Results:

  • Inertial effects enable enhanced mixing, particle separation, and bioparticle focusing.
  • Inertial microfluidic systems demonstrate robust and fault-tolerant operation.
  • High throughput rates are achievable with these systems.

Conclusions:

  • Inertial microfluidics presents a promising avenue for high-throughput applications.
  • Potential impact on environmental cleanup, physiological fluid processing, and clinical diagnostics.
  • Further research into microscale fluid inertia can unlock new applications.