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  1. Home
  3. Mapping And Engineering The Human Cell-cell Interactome.
  1. Home
  3. Mapping And Engineering The Human Cell-cell Interactome.

Related Experiment Video

Genome-wide Protein-protein Interaction Screening by Protein-fragment Complementation Assay (PCA) in Living Cells
08:38

Genome-wide Protein-protein Interaction Screening by Protein-fragment Complementation Assay (PCA) in Living Cells

Published on: March 3, 2015

Mapping and engineering the human cell-cell interactome.

Dino Di Carlo1, Leonardo Morsut2, Megan L McCain2

  • 1University of California, Los Angeles, Los Angeles, CA, USA. dicarlo@ucla.edu.

Nature Biotechnology
|June 23, 2026

View abstract on PubMed

Summary
This summary is machine-generated.

Scientists propose mapping the human cell-cell interactome to understand how cells communicate. This initiative aims to create a functional atlas for discovering new therapies by studying cell interactions.

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Area of Science:

  • Cell biology
  • Systems biology
  • Genomics

Background:

  • Single-cell transcriptomics and spatial profiling have advanced understanding of molecular states within tissues.
  • A significant knowledge gap exists regarding how cells influence each other within their microenvironment.
  • Understanding cell-cell communication is crucial for tissue-level function.

Purpose of the Study:

  • To propose an initiative for mapping and engineering the human cell-cell interactome.
  • To create a functional atlas detailing communication between major human cell types.
  • To leverage recent technological innovations to achieve this vision.

Main Methods:

  • Proposing the 'Billion Cell×Cell Project' as a first moonshot initiative.
  • Systematically characterizing the outcomes of defined cell-cell dyads.
  • Utilizing diverse cell types and experimental conditions.

    • Main Results:

    • The proposed initiative will generate a comprehensive map of cell-cell interactions.
    • It will provide insights into the functional consequences of cellular communication.
    • The project aims to unlock new avenues for therapeutic discovery.

    Conclusions:

    • Mapping the human cell-cell interactome is an achievable goal with current and emerging technologies.
    • This initiative promises to deepen our understanding of cellular communication.
    • Collaboration is called upon to build the necessary tools, datasets, and models.