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Related Experiment Video

Updated: Jun 19, 2026

Microfluidic Chips Controlled with Elastomeric Microvalve Arrays
18:11

Microfluidic Chips Controlled with Elastomeric Microvalve Arrays

Published on: October 1, 2007

Manufacturable plastic microfluidic valves using thermal actuation.

Karthik Pitchaimani1, Brian C Sapp, Adam Winter

  • 1Interdisciplinary Microsystems Group, Department of Mechanical and Aerospace Engineering, University of Florida, Gainesville, Florida 32611-6250, USA.

Lab on a Chip
|October 14, 2009
PubMed
Summary
This summary is machine-generated.

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A novel, low-cost plastic microfluidic valve uses a temperature-sensitive fluid for actuation. This thermally actuated valve, controlled by a printed circuit board (PCB), offers a scalable solution for fluid control in microfluidic devices.

Area of Science:

  • Materials Science
  • Microfluidics
  • Mechanical Engineering

Background:

  • Microfluidic devices require precise fluid control, often necessitating complex and expensive valve systems.
  • Existing microfluidic valves can be costly to manufacture and difficult to integrate into large-scale systems.

Purpose of the Study:

  • To develop a low-cost, manufacturable, and thermally actuated plastic microfluidic valve.
  • To demonstrate the valve's functionality and control capabilities for microfluidic applications.

Main Methods:

  • Fabrication of plastic microfluidic devices using compression molding and thermal lamination.
  • Development of a printed circuit board (PCB)-based controller for precise power input.
  • Investigation of valve operation via ionic conduction current measurements and fluorescence assays.

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Last Updated: Jun 19, 2026

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  • Characterization of valve performance under varying heater power and flow rates.

    • Main Results:

    • Successful development of a thermally actuated plastic microfluidic valve using an encapsulated, temperature-sensitive fluid.
    • Demonstrated valve control through deflection of an elastomeric film, confirmed by ionic current changes and fluorescence.
    • Characterized valve operation with heater power from 36 mW to 80 mW, resulting in local temperature increases of 10–19°C.
    • Achieved repeatable valve actuation (up to 50 cycles) for flow rates between 0.33–4.7 µL/min.

    Conclusions:

    • The developed microfluidic valve presents a cost-effective and scalable solution for fluid control.
    • The PCB-controlled thermal actuation mechanism is suitable for mass production and integration.
    • This technology holds promise for advancing microfluidic systems in various applications, including diagnostics and lab-on-a-chip devices.