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Updated: Jun 19, 2026

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Published on: April 10, 2026
[Risk factors for non-response in inpatient depression treatment]
Lars Hölzel1, Alessa von Wolff, Levente Kriston
1Universitätsklinikum Freiburg, Abteilung für Psychiatrie und Psychotherapie, Sektion Klinische Epidemiologie und Versorgungsforschung.
Objective:
The aim of this study was to identify predictors of non-response in inpatient depression treatment by means of routinely collected data from 10 psychiatric clinics.
Methods:
Evaluation was carried out through univariate analyses first; subsequently a model was developed by means of multivariate analyses.
Results:
About one third (31.5 %) of the 511 patients included in the study was classified as non-responder. Concerning patient level, psychic comorbidity, severity of depression symptoms and serious impairment of lifestyle as indication for hospitalisation have an impact on treatment outcome. In contrast, socio-demographic characteristics are not suitable as predictors. On the level of process characteristics, psychotherapy and patient compliance to medication enhanced the chance of profiting from inpatient treatment.
Conclusions:
The results can be integrated into a well interpretable model of the current inpatient depression treatment. Non-response is not yet sufficiently predictable through routine data.
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