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Related Concept Videos

Structure and Function of Platelets01:18

Structure and Function of Platelets

The cell fragments known as platelets are disc-shaped, with an average diameter of about 3 μm and a thickness of roughly 1 μm. They play a crucial role in the body's vascular clotting system, which also involves plasma proteins, blood cells, and blood vessel tissues.
Platelets are continually replenished, circulating in the bloodstream for 9-12 days before being removed by phagocytes, primarily in the spleen. A microliter of circulating blood contains between 150,000 and 450,000 platelets, with...

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Related Experiment Video

Updated: Jun 19, 2026

Microfluidics in Assessing Platelet Function
06:47

Microfluidics in Assessing Platelet Function

Published on: November 8, 2024

[Quantitative assessment of platelet morphofunctional activity based on the data from atomic force microscopy].

S A Orlov, M Iu Donnikov, A V Zinov'eva

    Klinicheskaia Laboratornaia Diagnostika
    |October 15, 2009
    PubMed
    Summary

    Atomic force microscopy can quantitatively assess platelet morphofunctional activity. Methanol fixation improves surface structure detection for platelet studies.

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    Dynamic Multiparameter Platelet Function Assessment Using a Capacitive Biosensor
    06:32

    Dynamic Multiparameter Platelet Function Assessment Using a Capacitive Biosensor

    Published on: May 2, 2025

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    Last Updated: Jun 19, 2026

    Microfluidics in Assessing Platelet Function
    06:47

    Microfluidics in Assessing Platelet Function

    Published on: November 8, 2024

    Dynamic Multiparameter Platelet Function Assessment Using a Capacitive Biosensor
    06:32

    Dynamic Multiparameter Platelet Function Assessment Using a Capacitive Biosensor

    Published on: May 2, 2025

    Area of Science:

    • Biophysics
    • Hematology

    Context:

    • Platelet function is crucial for hemostasis and thrombosis.
    • Quantitative assessment of platelet activity is vital for diagnosing and managing bleeding disorders and thrombotic events.

    Purpose:

    • To investigate the utility of atomic force microscopy (AFM) for the quantitative assessment of platelet morphofunctional activity.
    • To determine optimal sample preparation methods for AFM analysis of platelets.

    Summary:

    • Atomic force microscopy (AFM) was employed to study platelet morphofunctional activity.
    • Methanol fixation was found to enhance the detectability of surface structure details on platelets.
    • AFM proved effective for analyzing platelet functional activity in donor platelet concentrate specimens.

    Impact:

    • This study demonstrates a novel application of AFM in hematology.
    • The findings provide a foundation for developing new diagnostic tools for platelet disorders.
    • Improved quantitative assessment of platelet function can lead to more personalized therapeutic strategies.