[Drug sedation during digestive tract endoscopy: current trends]

Area of Science:

• Anesthesiology and Pharmacology
• Gastroenterology

Context:

• Medical sedation is crucial for patient comfort and procedural success.
• Existing sedative agents have limitations, including respiratory depression and hemodynamic instability.
• Ketamine and propofol are commonly used sedatives, but their combined use (ketofol) requires careful consideration of ratios and effects.

Purpose:

• To evaluate the clinical efficacy and safety of ketofol for sedation during digestive tract endoscopic interventions.
• To identify optimal ketamine/propofol ratios for effective sedation with minimal adverse effects.
• To analyze foreign experiences and prerequisites for ketofol mixture design.

Summary:

• A study involving 152 patients undergoing endoscopic procedures demonstrated that ketofol sedation effectively reduced the need for additional analgesia and other drugs.
• Ketofol exhibited minimal impact on respiration and blood pressure, indicating a favorable safety profile.
• An optimal ketamine/propofol ratio of 1:4 was identified, providing sufficient analgesia and hemodynamic stability without compromising procedural control.

Impact:

• Ketofol provides a safe and effective alternative for medical sedation, potentially reducing opioid reliance.
• The optimal 1:4 ratio ensures adequate pain relief and stable hemodynamics, enhancing patient comfort and procedural outcomes.
• This approach offers more controlled sedation compared to individual agent administration, with no adverse effect on psychomotor recovery.