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Self-assembly of Complex Two-dimensional Shapes from Single-stranded DNA Tiles
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Published on: May 8, 2015

DNA prism structures constructed by folding of multiple rectangular arms.

Masayuki Endo1, Kumi Hidaka, Takayuki Kato

  • 1Institute for Integrated Cell-Material Sciences (iCeMS), Kyoto University, Kitashirakawa-oiwakecho, Sakyo-ku, Kyoto 606-8502, Japan. endo@kuchem.kyoto-u.ac.jp

Journal of the American Chemical Society
|October 15, 2009
PubMed
Summary

Researchers designed novel multiarm DNA structures using 2D DNA origami scaffolds, folding them into hollow 3D shapes. High-speed atomic force microscopy revealed the dissociation of connecting arms in these 3D DNA structures.

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Area of Science:

  • Nanotechnology
  • Biochemistry
  • Structural Biology

Background:

  • DNA origami enables the precise nanoscale assembly of complex structures.
  • Creating hollow three-dimensional (3D) DNA nanostructures presents challenges in stability and controlled opening.

Purpose of the Study:

  • To design and fabricate novel multiarm DNA structures using 2D DNA origami scaffolds.
  • To investigate the folding of these 2D scaffolds into hollow 3D structures.
  • To analyze the opening mechanism of the resulting 3D DNA structures.

Main Methods:

  • Design of multiarm DNA structures utilizing 2D DNA origami templates.
  • Folding of 2D scaffolds into hollow 3D prism structures via connection strands.
  • High-speed atomic force microscopy (HS-AFM) for real-time imaging of structural dynamics.

Main Results:

  • Successful design and folding of multiarm DNA structures into hollow 3D prisms.
  • HS-AFM imaging visualized the opening process of the 3D structures.
  • Observation of the dissociation of connecting arms as the mechanism for structure opening.

Conclusions:

  • The study demonstrates a method for creating switchable hollow 3D DNA nanostructures.
  • The findings provide insights into the dynamic behavior and controlled disassembly of DNA origami structures.
  • This work contributes to the development of DNA-based nanomaterials for potential applications in drug delivery and molecular assembly.