Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Skin Cancer

Skin Cancer

Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...

Depression: Overview

Depression: Overview

Depression is a prevalent mental illness marked by persistent sadness and lack of interest in previously enjoyable activities. It can take several forms, including major depression, persistent depressive disorder, and bipolar I and II disorders. Symptoms range from emotional changes like chronic worry to physical changes like sleep disturbances and suicidal thoughts. From a neurobiological perspective, depression is believed to be triggered by abnormalities in the brain's prefrontal cortex,...

Long-term Depression

Long-term Depression

Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.

Long-term Depression

Long-term Depression

Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
Calcium Ion Concentration Mechanism
If over time, all...

Depressive Disorders: Etiology

Depressive Disorders: Etiology

Depressive disorders result from a complex interplay of biological, psychological, and sociocultural factors, each contributing uniquely to the development and persistence of the condition. Understanding these factors provides critical insight into the multifaceted nature of depression.
Biological Factors in Depression
Biological predispositions significantly influence the risk of developing depressive disorders. Genetic studies highlight the role of variations in the serotonin transporter...

Psychoneuroimmunology: Diabetes and Cancer

Psychoneuroimmunology: Diabetes and Cancer

Chronic stress has been linked to both the onset and progression of serious health conditions, including Type 2 diabetes and cancer. Type 2 diabetes, a widespread chronic illness, is closely associated with obesity and insulin resistance, both of which often worsen under stress. Studies indicate that men experiencing high levels of chronic stress face a 45% higher risk of developing diabetes compared to those with minimal stress. Stress triggers physiological responses that elevate blood...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Microdosing of Flywheel Training: Effects of Low Versus High Training Frequency on Muscle Mass, Strength, and Power.

International journal of sports physiology and performance·2026

Same author

Identifying germline pathogenic variants in breast cancer using tumor sequencing.

Breast (Edinburgh, Scotland)·2025

Same author

Comprehensive histopathological analysis of gastric cancer in European and Latin America populations reveals differences in PDL1, HER2, p53 and MUC6 expression.

Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association·2025

Same author

Efficient extraction of textile dyes using reusable acrylic-based smart polymers.

Journal of hazardous materials·2024

Same author

Acne keloidalis nuchae: An international multicentric review of 79 patients.

Journal of the European Academy of Dermatology and Venereology : JEADV·2023

Same author

From Classical to Advanced Use of Polymers in Food and Beverage Applications.

Polymers·2022

Search research articles

Related Experiment Video

Updated: Jun 19, 2026

A 3D Organotypic Melanoma Spheroid Skin Model

A 3D Organotypic Melanoma Spheroid Skin Model

Published on: May 18, 2018

Giant melanoma and depression.

Javier del Boz¹, José Miguel García, Silvestre Martínez

¹Dermatology Department, Complejo Hospitalario Carlos Haya, Málaga, Spain. javierdelboz@yahoo.es

American Journal of Clinical Dermatology

|October 15, 2009

Summary

A rare, giant primary cutaneous melanoma case highlights delayed diagnosis due to major depression. This case underscores the critical link between mental health and timely cancer detection and treatment.

Area of Science:

Dermatology
Oncology
Psychiatry

Background:

Melanoma is a significant skin cancer with varying presentations.
Delayed diagnosis can lead to advanced disease and poorer prognoses.
The interplay between mental health and physical health is increasingly recognized.

Observation:

A 29-year-old female presented with a massive primary cutaneous melanoma on her left arm.
The patient had co-occurring major depression, which contributed to avoiding medical consultation.
The melanoma was the largest primary cutaneous melanoma ever reported, with multiple visceral metastases.

Findings:

The patient's major depression delayed the diagnosis and treatment of her extensive melanoma.
Surgical excision was performed palliatively, but the patient died one month post-operation.

More Related Videos

Ex Vivo Culture of Circulating Tumor Cells in the Cerebral Spinal Fluid from Melanoma Patients to Study Melanoma-Associated Leptomeningeal Disease

Ex Vivo Culture of Circulating Tumor Cells in the Cerebral Spinal Fluid from Melanoma Patients to Study Melanoma-Associated Leptomeningeal Disease

Published on: March 29, 2024

Related Experiment Videos

Last Updated: Jun 19, 2026

A 3D Organotypic Melanoma Spheroid Skin Model

A 3D Organotypic Melanoma Spheroid Skin Model

Published on: May 18, 2018

Ex Vivo Culture of Circulating Tumor Cells in the Cerebral Spinal Fluid from Melanoma Patients to Study Melanoma-Associated Leptomeningeal Disease

Ex Vivo Culture of Circulating Tumor Cells in the Cerebral Spinal Fluid from Melanoma Patients to Study Melanoma-Associated Leptomeningeal Disease

Published on: March 29, 2024

The case suggests a potential link between the dermatologic condition and the patient's depression.

Implications:

This case emphasizes the importance of addressing mental health to facilitate early cancer diagnosis.
It highlights the potential for severe, advanced presentations of cutaneous melanoma.
Further research is needed to understand the bidirectional relationship between depression and melanoma progression.