Related Experiment Video
Updated: Jun 19, 2026
14:44
Scalable Fabrication of Stretchable, Dual Channel, Microfluidic Organ Chips
Published on: October 20, 2018
Recent trends and challenges in complex organ manufacturing
Xiaohong Wang1, Yongnian Yan, Renji Zhang
1Center of Organ Manufacturing & Key Laboratory for Advanced Materials Processing Technology, Ministry of Education, Department of Mechanical Engineering, Tsinghua University, Beijing, 100084, P.R. China.
Tissue Engineering. Part B, Reviews
|October 15, 2009
Summary
Bioartificial organs are crucial for treating organ failures. Advanced rapid prototyping techniques enable the automated assembly of complex vascular systems and multicellular structures for engineered organs.
Area of Science:
- Biotechnology
- Tissue Engineering
- Regenerative Medicine
Background:
- There is a critical need for bioartificial organs to address organ failures.
- Advances in transgenosis, tissue engineering, and rapid prototyping facilitate the creation of complex tissues.
- Ideal artificial organs require integrated nutrient transport, mechanical stability, and multicellular organization.
Purpose of the Study:
- To provide an overview of current trends and challenges in organ manufacturing.
- To highlight future directions in the field of bioartificial organ development.
Main Methods:
- Utilizing multinozzle rapid prototyping for simultaneous assembly of vascular systems and multicellular structures.
- Employing automated and reproducible techniques for organ construction.
Main Results:
- Demonstration of rapid prototyping's capability to create hierarchical multicellular structures.
- Successful integration of vascular systems within engineered tissue constructs.
Conclusions:
- Rapid prototyping offers a viable approach for developing bioartificial organs.
- Interdisciplinary integration is key to advancing organ manufacturing and addressing future challenges.
