Related Experiment Video
Updated: Apr 14, 2026
11:28
3D Microtissues for Injectable Regenerative Therapy and High-throughput Drug Screening
Published on: October 4, 2017
10.9K
Bottom-Up Engineering of Well-Defined 3D Microtissues Using Microplatforms and Biomedical Applications
Geon Hui Lee1, Jae Seo Lee1, Xiaohong Wang2
1KU-KIST Graduate School of Converging, Science and Technology, Korea University, Seoul, 136-701, Republic of Korea.
Advanced Healthcare Materials
|April 17, 2015
Summary
This review explores microscale devices for engineering 3D tissues, offering in vivo mimicking environments for bioartificial organ development. Microplatforms enable precise assembly of diverse 3D microtissues for biomedical applications.
Area of Science:
- Biomedical Engineering
- Tissue Engineering
- Microtechnology
Background:
- 3D tissue engineering is crucial for creating in vivo mimicking environments.
- It serves as a foundation for developing bioartificial organs.
- Microscale devices offer advanced capabilities for precise tissue construction.
Purpose of the Study:
- To review diverse engineering methods for 3D tissues using microscale devices.
- To highlight recent advancements in microtechnology for 3D tissue assembly.
- To discuss applications and future directions in microplatform-based 3D tissue engineering.
Main Methods:
- Utilizing microplatforms for bottom-up assembly of 3D tissues.
- Employing micro hanging-drop plates, microfluidic chips, and arrayed microwells.
- Encapsulating cells in hydrogel microspheres and microfibers for 3D microtissue formation.
Main Results:
- Microtechnologies enable the development of diverse shaped 3D tissues with various cells.
- Hydrogel encapsulation facilitates the creation of 3D microtissues with controlled shapes.
- Microplatforms provide precise control over tissue architecture and cellular composition.
Conclusions:
- Microscale devices are powerful tools for engineering complex 3D microtissues.
- These engineered tissues have significant potential in various biomedical fields.
- Continued advancements in microplatforms will drive innovation in tissue engineering and regenerative medicine.
